Evidence map›Paper›PMID 36271030›Full record

ArticleOncogene2022

A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify

Lin Ming Lee, Eleni G Christodoulou, Pavithra Shyamsunder, Bei Jun Chen, Kian Leong Lee, Tsz Kan Fung, Chi Wai Eric So, Gee Chuan Wong, Enrico Petretto, Owen J L Rackham and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Lin Ming Lee *Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-6229-3679
Eleni G Christodoulou *Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-9209-8425
Pavithra ShyamsunderProgramme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.
Bei Jun ChenCentre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore.
Kian Leong LeeProgramme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-0443-2746
Tsz Kan FungComprehensive Cancer Centre, King's College London, London, UK.
Chi Wai Eric SoComprehensive Cancer Centre, King's College London, London, UK.ORCID 0000-0002-4117-0036
Gee Chuan WongDepartment of Haematology, Singapore General Hospital, Singapore, Singapore.
Enrico PetrettoCentre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore. enrico.petretto@duke-nus.edu.sg.ORCID 0000-0003-2163-5921
Owen J L RackhamCentre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore. owen.rackham@duke-nus.edu.sg.ORCID 0000-0002-4390-0872
S Tiong OngProgramme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. sintiong.ong@duke-nus.edu.sg.ORCID 0000-0001-9460-3483
Duke-NUS Medical School · SGKing's College London · GBChina Pharmaceutical University · CNDuke University · USSingapore General Hospital · SG

Funding

Cancer Research UK 29213
6 · The paper itself

Abstract

Acute myeloid leukaemia (AML) is a rapidly fatal blood cancer that is characterised by the accumulation of immature myeloid cells in the blood and bone marrow as a result of blocked differentiation. Methods which identify master transcriptional regulators of AML subtype-specific leukaemia cell states and their combinations could be critical for discovering novel differentiation-inducing therapies. In this proof-of-concept study, we demonstrate a novel utility of the Mogrify

Indexed as

Leukemia, Myeloid, AcuteLeukemia, Promyelocytic, AcuteCell DifferentiationHumansNetwork PharmacologyOncogene Proteins, FusionTranscription FactorsTretinoinOncogene Proteins, FusionTranscription FactorsTretinoin

Identifiers

PMID36271030
OpenAlexW4306990472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.