Evidence map›Paper›PMID 36270991›Full record

ArticleNature communications2022

Long-term whole blood DNA preservation by cost-efficient cryosilicification.

Liang Zhou, Qi Lei, Jimin Guo, Yuanyuan Gao, Jianjun Shi, Hong Yu, Wenxiang Yin, Jiangfan Cao, Botao Xiao, Jacopo Andreo and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Oocyte-inspired universal whole-cell vaccines against tumor heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025
    Review
  8. Deep silicification-assisted long-term preservation of structural and genomic information across biospecies: From micro to macro.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Improving normothermic machine perfusion and blood transfusion through biocompatible blood silicification.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. DNA Data Storage.Biotech (Basel (Switzerland)) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liang Zhou *MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Qi Lei *MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Jimin Guo *Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, NM, 87131, USA.
Yuanyuan GaoMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Jianjun ShiScience and Technology on Advanced Functional Composites Technology, Aerospace Research Institute of Materials & Processing Technology, Beijing, 100076, P. R. China.
Hong YuMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Wenxiang YinMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Jiangfan CaoMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Botao XiaoMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.ORCID 0000-0002-0785-1006
Jacopo AndreoBCMaterials, Basque Center for Materials, UPV/EHU Science Park, 48940, Leioa, Spain.ORCID 0000-0002-8153-5802
Romy EttlingerSchool of Chemistry, University of St. Andrews, St. Andrews, United Kingdom.
C Jeffrey BrinkerCenter for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, NM, 87131, USA.ORCID 0000-0002-7145-9324
Stefan WuttkeBCMaterials, Basque Center for Materials, UPV/EHU Science Park, 48940, Leioa, Spain. stefan.wuttke@bcmaterials.net.ORCID 0000-0002-6344-5782
Wei ZhuMOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China. weizhu86@scut.edu.cn.ORCID 0000-0003-3240-6905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/person. Additionally, our demonstration of 3D-printed DNA banking artefacts, could potentially allow 'artificial fossilization'.

Indexed as

DNAUltraviolet RaysBlood PreservationHumansOxygenPreservation, BiologicalDNAOxygen

Identifiers

PMID36270991
PMCPMC9587218

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.