Evidence map›Paper›PMID 36270740›Full record

ArticleRMD open2022

Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium.

William Murray-Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon, Malcolm D Smith, Susan E Lester, Susanna M Proudman, Navin L Rao, Ling-Yang Hao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  15. Characteristics of PD-1Clinical & translational immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William Murray-BrownDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia.
Yanxia GuoDiscovery Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA.
Annabelle SmallDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia.ORCID 0000-0001-6275-2847
Katie LoweDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia.
Helen WeedonDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia.
Malcolm D SmithDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia.
Susan E LesterRheumatology Research Group, Basil Hetzel Institute for Medical Research, Woodville South, South Australia, Australia.
Susanna M ProudmanDepartment of Rheumatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Navin L RaoDiscovery Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA.
Ling-Yang HaoDiscovery Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA.
Sunil NagpalDiscovery Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA.
Mihir D WechalekarDepartment of Rheumatology, Flinders University, Bedford Park, South Australia, Australia mihir.wechalekar@sa.gov.au.ORCID 0000-0001-6668-9638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesProgrammed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5

methodsFresh dissociated tissue and peripheral blood mononuclear cell (PBMC) suspensions were stained with Zombie UV, followed by anti-CD45RO, PD-1, CD3, ICOS, CD8, CD4, CD20, CXCR5, TIGIT and CD38 antibodies prior to analysis. For histology, rheumatoid arthritis synovial sections were prepared for Opal multispectral immunofluorescence with anti-CD45RO, CD20, PD-1 and CXCR5 antibodies. Images were acquired on the Perkin Elmer Vectra V.3.0 imaging system and analysed using InForm Advanced Image Analysis software.

resultsFlow cytometry revealed T cell infiltration in the rheumatoid arthritis synovium with differential expression of PD-1, CD45RO, ICOS, TIGIT and CD38. We observed a higher frequency of PD1

conclusionsThese data demonstrate that PD-1

Indexed as

Arthritis, RheumatoidOsteoarthritisHumansLeukocytes, MononuclearProgrammed Cell Death 1 ReceptorReceptors, CXCR5Synovial MembraneT-Lymphocytes, Helper-InducerProgrammed Cell Death 1 ReceptorReceptors, CXCR5Rheumatoid ArthritisT CellsT-Lymphocyte subsets

Identifiers

PMID36270740
PMCPMC9594577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.