Evidence map›Paper›PMID 36270290›Full record

ReviewAnnual review of physiology2023

Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver.

Stacey S Huppert, Robert E Schwartz

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stacey S HuppertDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; email: Stacey.Huppert@cchmc.org.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA; email: res2025@med.cornell.edu.
Cincinnati Children's Hospital Medical Center · USCornell University · US

Funding

Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0M
Optimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6M
Building a functional biliary system from hepatocytesR01DK107553 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HUPPERT, STACEY S, WILLENBRING, HOLGER · 2016 to 2020
$2.4M
Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsR01CA234614 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2019 to 2023
$1.9M
Molecular regulation of hepatic cell differentiation and maturationR01DK120765 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HUPPERT, STACEY S · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA234614NIAID NIH HHS R01 AI107301NIDDK NIH HHS R01 DK107553NIDDK NIH HHS R01 DK120765NIDDK NIH HHS R01 DK121072
6 · The paper itself

Abstract

Liver regeneration occurs in response to diverse injuries and is capable of functionally reestablishing the lost parenchyma. This phenomenon has been known since antiquity, encapsulated in the Greek myth where Prometheus was to be punished by Zeus for sharing the gift of fire with humanity by having an eagle eat his liver daily, only to have the liver regrow back, thus ensuring eternal suffering and punishment. Today, this process is actively leveraged clinically during living donor liver transplantation whereby up to a two-thirds hepatectomy (resection or removal of part of the liver) on a donor is used for transplant to a recipient. The donor liver rapidly regenerates to recover the lost parenchymal mass to form a functional tissue. This astonishing regenerative process and unique capacity of the liver are examined in further detail in this review.

Indexed as

Liver TransplantationAnimalsHepatectomyHomeostasisHumansLiverLiver RegenerationLiving DonorsMammalsacute and chronic injurycellular plasticityheterogeneityhomeostasisliver regenerationliver zonation

Identifiers

PMID36270290
PMCPMC9918695
OpenAlexW4307021368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.