Evidence map›Paper›PMID 36269876›Full record

ArticleAnalytical chemistry2022

Second Harmonic Generation Interrogation of the Endonuclease APE1 Binding Interaction with G-Quadruplex DNA.

Aaron M Fleming, Renee Tran, Carla A Omaga, Shereen A Howpay Manage, Cynthia J Burrows, John C Conboy

Abstract read
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Position-Dependent Effects of AP Sites Within anInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. PromotersRSC chemical biology · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaron M FlemingDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.ORCID 0000-0002-2000-0310
Renee TranDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.
Carla A OmagaDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.ORCID 0000-0002-9189-6812
Shereen A Howpay ManageDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.
Cynthia J BurrowsDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.ORCID 0000-0001-7253-8529
John C ConboyDepartment of Chemistry, University of Utah, 315 S 1400 East, Salt Lake City, Utah84112-0850, United States.ORCID 0000-0003-0023-642X

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
OXIDATIVE STRESS AND BASE MODIFICATIONS IN REGULATORY DNAR01GM129267 · NIGMS · UNIVERSITY OF UTAH · PI BURROWS, CYNTHIA J · 2018 to 2021
$1.2M
NCI NIH HHS P30 CA042014NIGMS NIH HHS R01 GM129267
6 · The paper itself

Abstract

The binding interaction between the DNA repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) with promoter G-quadruplex (G4) folds bearing an abasic site (AP) can serve as a gene regulatory switch during oxidative stress. Prior fluorescence-based analysis in solution suggested APE1 binds the

Indexed as

G-QuadruplexesSecond Harmonic Generation MicroscopyDNADNA-(Apurinic or Apyrimidinic Site) LyaseDNA RepairEndonucleasesVascular Endothelial Growth Factor ADNADNA-(Apurinic or Apyrimidinic Site) LyaseEndonucleasesVascular Endothelial Growth Factor A

Identifiers

PMID36269876
PMCPMC9945475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.