ArticleProceedings of the National Academy of Sciences of the United States of America2022
Metabolome-wide association study on
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- UK Biobank at 20 - a growing, global resource for dementia research.Nature reviews. Neurology · 2026Review
- Diet, Metabolism and Synaptic Function: Integrating Evidence Across Models in Neurodegeneration Research.Biomedicines · 2026Review
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- Cross-platform metabolomics imputation using importance-weighted autoencoders.NPJ systems biology and applications · 2026Article
- Exploring ceramide as a novel biomarker and therapeutic target for Alzheimer's disease.Frontiers in neuroscience · 2026Review
- The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system.Brain pathology (Zurich, Switzerland) · 2026Review
- Alterations in the brain lipidome of Alzheimer's disease donors with rareBrain communications · 2026Article
- Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.Aging cell · 2025Article
- Assessing the causal role of lipid metabolites in Alzheimer's disease: A mendelian randomization study.The journal of prevention of Alzheimer's disease · 2025Article
- Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research.Molecular neurodegeneration · 2025Review
- Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model.The Analyst · 2025Article
- Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer's disease continuum.Alzheimer's research & therapy · 2025Article
- Fundamental Neurochemistry Review: Lipids across microglial states.Journal of neurochemistry · 2025Review
- The early diagnosis of Alzheimer's disease: Blood-based panel biomarker discovery by proteomics and metabolomics.CNS neuroscience & therapeutics · 2024Review
- Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine.Annual review of biomedical data science · 2024Review
- Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2024Review
- Alzheimer's genes in microglia: a risk worth investigating.Molecular neurodegeneration · 2023Review
- A Multiplexed Urinary Biomarker Panel Has Potential for Alzheimer's Disease Diagnosis Using Targeted Proteomics and Machine Learning.International journal of molecular sciences · 2023Article
- Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease.Trends in neurosciences · 2023Review
- Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing?International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
29 authors at 4 institutions in 9 countries.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.ORCID 0000-0001-6403-016X
Rui Climaco PintoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
Ibrahim KaramanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
Jian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
Brenan R DurainayagamDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
Mohsen GhanbariDepartment of Epidemiology, Erasmus Medical Center, Rotterdam 3000, the Netherlands.
Areesha NazeerBiomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
Qi ZhongUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.ORCID 0000-0002-5893-1807
Sonia LiggiBiomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom.
Luke WhileyAustralian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0002-9088-4799
Rima MustafaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.ORCID 0000-0003-2623-5337
Miia KivipeltoInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Alina SolomonAgeing Epidemiology Research Unit, School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom.
Tiia NganduDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 17177, Sweden.
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.ORCID 0000-0001-6751-9374
Tomonori AikawaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.ORCID 0000-0003-4189-1156
Carola I RadulescuUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
Samuel J BarnesUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.ORCID 0000-0003-4030-6453
Gonçalo GraçaSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.
Elena ChekmenevaNational Phenome Centre, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0003-1807-2398
Stephane CamuzeauxNational Phenome Centre, Imperial College London, London W12 0NN, United Kingdom.
Matthew R LewisNational Phenome Centre, Imperial College London, London W12 0NN, United Kingdom.
Manuja R KaluarachchiUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.ORCID 0000-0003-3769-8310
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam 3000, the Netherlands.
Elaine HolmesUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.ORCID 0000-0002-0556-8389
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.
Paul M MatthewsUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.ORCID 0000-0002-1619-8328
Julian L GriffinUK Dementia Research Institute at Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London SW7 2AZ, United Kingdom.ORCID 0000-0002-7511-5684
Ipsen (France) · FRMurdoch University · AUUniversity of Eastern Finland · FIAgency for Science, Technology and Research · SG
Funding
British Heart FoundationDepartment of HealthMedical Research Council MC_PC_12025Medical Research Council MC_PC_13030Medical Research Council MC_UP_A090_1006Medical Research Council MR/L01341X/1Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1Medical Research Council MR/R023484/1Medical Research Council MR/S010483/1Wellcome TrustWellcome Trust 206046/Z/17/Z
Abstract
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (MWAS) of AD-associated loci from GWASs using untargeted metabolic profiling (metabolomics) by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). We identified an association of lactosylceramides (LacCer) with AD-related single-nucleotide polymorphisms (SNPs) in
Indexed as
Alzheimer DiseaseATP-Binding Cassette TransportersCeramidesAnimalsChromatography, LiquidGenome-Wide Association StudyLactosylceramidesMetabolomeMiceMice, KnockoutSphingomyelinsTandem Mass SpectrometryAbca7 protein, mouseATP-Binding Cassette TransportersCeramidesLactosylceramidesSphingomyelinsABCA7Alzheimer’s diseaseceramidegenome-wide association studymetabolomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.