ArticleScience advances2022
Diffusion and bulk flow of amino acids mediate calcium waves in plants.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding.The New phytologist · 2026Review
- Unraveling the crosstalk between extracellular ATP and glutamate in systemic ROS signaling.Plant physiology · 2026Article
- Plasmodesmata display dynamic local and systemic redox responses during plant stress.The Plant cell · 2026Article
- Plasmodesmal closure elicits stress responses.EMBO reports · 2026Article
- The power of ionic movements in plants.The New phytologist · 2026Review
- MAcro Plant Projection Imaging (MAPPI): An open, scalable platform for whole-plant fluorescence real-time imaging.Science advances · 2026Article
- Graft compatibility emerges from the balance between regeneration and immunity: lessons from plant-plant interactions.Frontiers in plant science · 2026Review
- Mechanisms of Induction of Stimulus-Specific Systemic Responses of Photosynthesis in Wheat Plants.International journal of molecular sciences · 2025Article
- Jasmonic acid and salicylic acid interact to determine spatial regulation of gene expression responses in potato leaf to herbivory by Colorado potato beetle and mechanical wounding.Plant & cell physiology · 2025Article
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- Dynamic Hydrogel-Based Cytomimetic Models for Chemical Information Conduction.Small science · 2025Article
- RBOHD, GLR3.3, and GLR3.6 cooperatively control wounding hypocotyl-induced systemic CaPlant diversity · 2025Article
- CaEMBO reports · 2025Article
- A unified framework for hydromechanical signaling can explain transmission of local and long-distance signals in plants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Damage activates EXG1 and RLP44 to suppress vascular differentiation during regeneration in Arabidopsis.Plant communications · 2025Article
- Transdisciplinary Collaborations for Advancing Sustainable and Resilient Agricultural Systems.Global change biology · 2025Article
- The photosensitive endoplasmic reticulum-chloroplast contact site.Journal of microscopy · 2025Article
- Glutathione triggers leaf-to-leaf, calcium-based plant defense signaling.Nature communications · 2025Article
- A bi-kinase module sensitizes and potentiates plant immune signaling.Science advances · 2025Article
- Combined effects of calcium sources and water restriction on fruit yield and quality of 'Ataulfo' and 'Kent' mangoes.Frontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
In plants, a variety of stimuli trigger long-range calcium signals that travel rapidly along the vasculature to distal tissues via poorly understood mechanisms. Here, we use quantitative imaging and analysis to demonstrate that traveling calcium waves are mediated by diffusion and bulk flow of amino acid chemical messengers. We propose that wounding triggers release of amino acids that diffuse locally through the apoplast, activating the calcium-permeable channel GLUTAMATE RECEPTOR-LIKE 3.3 as they pass. Over long distances through the vasculature, the wound-triggered dynamics of a fluorescent tracer show that calcium waves are likely driven by bulk flow of a channel-activating chemical. We observed that multiple stimuli trigger calcium waves with similar dynamics, but calcium waves alone cannot initiate all systemic defense responses, suggesting that mobile chemical messengers are a core component of complex systemic signaling in plants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.