ArticlePloS one2022
Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 26 citations in OpenAlex.
- Functional role of manganese nanoparticles in broiler diets: Impacts on growth, antioxidant status, immune response, blood minerals, digestive enzymes, carcass traits, and cecal bacterial counts.Poultry science · 2026Article
- Serum trace element levels and their associations with handgrip strength: a cross-sectional study among non-diabetic older adults in Germany.GeroScience · 2026Article
- Women's bone health trajectories from pregnancy to postpartum: Associations with bone-seeking metal exposure mixtures during pregnancy.Ecotoxicology and environmental safety · 2025Article
- Associations of cadmium exposure within heavy metal combinations with osteoporosis risk: an analysis of NHANES data (2013-2014 and 2017-2018).Aging clinical and experimental research · 2025Article
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- Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents.BMC musculoskeletal disorders · 2025Article
- Article
- Analysis of the association between mixed exposure to multiple metals and comorbidity of osteopenia or osteoporosis: baseline data from the Chinese Multi-Ethnic Cohort study (CMEC).BMC public health · 2025Article
- Utilization of Pineapple Fruit Waste in Greener Alternative Agents for Thai Silk Pretreatment and Acid Dyeing Wastewater Treatment.Materials (Basel, Switzerland) · 2025Article
- Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis.Biological trace element research · 2024Article
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.Journal of clinical medicine · 2024Review
- Green strength: The role of micronutrients in plant-based diets for athletic performance enhancement.Heliyon · 2024Review
- Article
- Manganese and Sleep Outcomes in United States Adults: Results from the 2017-2020 National Health and Nutrition Examination Survey (NHANES).The Journal of nutrition · 2024Article
- Article
- Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture.Frontiers in immunology · 2024Article
- Chloroform associated with bone mineral density and bone mineral content in adults: A population-based cross-sectional research.PloS one · 2024Article
- The association of manganese levels with red cell distribution width: A population-based study.PloS one · 2024Article
- Associations of blood trace elements with bone mineral density: a population-based study in US adults.Journal of orthopaedic surgery and research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES).
methodsA total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed.
resultsWe observed a negative association between blood manganese and BMD/BMC in the femoral neck and total body in the fully adjusted model, especially femoral neck BMD in women aged 50-70 years.
conclusionIn brief, people exposed to manganese should be aware of the increased risk of osteopenia or osteoporosis. Besides, due to the lack of available data, there are no definite values for the tolerable upper intake level (UL), average requirement (AR) and population reference intake (PRI) of manganese. The results of our study may provide some references for the establishment of AR, PRI and UL of Mn.
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