ArticlePloS one2022
Gait variability during abrupt slow and fast speed transitions in older adults with mild cognitive impairment.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Relationship Between Cognitive Abilities and Lower-Limb Movements: Can Analyzing Gait Parameters and Movements Help Detect Dementia? A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- A novel therapeutic regimen based on the constrained-disorder principles may improve the response to dimethyl fumarate in multiple sclerosis: Findings from an exploratory feasibility open-label clinical trial.IBRO neuroscience reports · 2026Article
- Recovery strategies during trip-like support surface perturbations while walking in older adults with mild cognitive impairment.GeroScience · 2026Article
- Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System.Current aging science · 2026Article
- Altered regularity and stability of multi-finger force production in individuals with mild cognitive impairment.Frontiers in human neuroscience · 2026Article
- Review
- Effectiveness of digital screening tools in detecting cognitive impairment among community-dwelling elderly in Northern China: A large cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- The Constrained Disorder Principle Overcomes the Challenges of Methods for Assessing Uncertainty in Biological Systems.Journal of personalized medicine · 2024Review
- Free Will as Defined by the Constrained Disorder Principle: a Restricted, Mandatory, Personalized, Regulated Process for Decision-Making.Integrative psychological & behavioral science · 2024Review
- The Co-Piloting Model for Using Artificial Intelligence Systems in Medicine: Implementing the Constrained-Disorder-Principle-Based Second-Generation System.Bioengineering (Basel, Switzerland) · 2024Review
- Using the Constrained Disorder Principle to Navigate Uncertainties in Biology and Medicine: Refining Fuzzy Algorithms.Biology · 2024Review
- Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia.Experimental brain research · 2024Article
- Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.Sensors (Basel, Switzerland) · 2024Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- Gait smoothness during high-demand motor walking tasks in older adults with mild cognitive impairment.PloS one · 2024Article
- Identifying essential factors for energy-efficient walking control across a wide range of velocities in reflex-based musculoskeletal systems.PLoS computational biology · 2024Article
- Harnessing Variability Signatures and Biological Noise May Enhance Immunotherapies' Efficacy and Act as Novel Biomarkers for Diagnosing and Monitoring Immune-Associated Disorders.ImmunoTargets and therapy · 2024Article
- Exploring the Intricate Nexus of Sarcopenia and Cognitive Impairment.Aging and disease · 2023Review
- Association between motoric cognitive risk syndrome and future falls among Chinese community-dwelling elderly: A nationwide cohort study.Brain and behavior · 2023Article
- Using dual-task gait to recognize Alzheimer's disease and mild cognitive impairment: a cross-sectional study.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait speed modulation, including abruptly decreasing or increasing gait speed, is a challenging task and prerequisite for safe mobility in the community. Older adults with Mild Cognitive Impairment (MCI) exhibit gait deficits under challenging walking conditions which may increase their risk of falls. The purpose of this study was to investigate spatiotemporal variability during slow and fast speed transitions in older adults with and without MCI. Twenty-five older adults with MCI (mean age = 68.56 ± 3.79 years) and 25 cognitively intact controls (mean age = 68.72 ± 4.67 years) participated. Gait performance during gait speed transitions was measured in two walking conditions: 1) a slow to fast speed transition in response to a randomly presented cue, and 2) a fast to slow speed condition in response to a randomly presented cue. Means and variability of spatiotemporal parameters during the transitions were measured and mixed model repeated measures ANOVAs were used to assess interaction and main effects. The older adults with MCI exhibited greater variability of step length (MCI = 13.93 ± 5.38, Control = 11.12 ± 3.15, p = 0.03) and swing time (MCI = 13.35 ± 6.01, Control = 10.43 ± 2.87, p = 0.03) than the controls during the fast to slow speed transitions. No other between-group differences were evident for the gait parameters across the two walking conditions. The findings suggest that older adults with MCI have reduced ability to adapt their gait during transitions from fast to slow walking speeds. This impairment may indicate a decline in automated regular rhythmic gait control and explain in part why this group is at increased risk of falls. Slow speed transition task might be incorporated as a fall risk screening in older adults with MCI.
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