Evidence map›Paper›PMID 36269643›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Sex differences in microvascular function and arterial hemodynamics in nondialysis chronic kidney disease.

Danielle L Kirkman, Meghan G Ramick, Bryce J Muth, Joseph M Stock, Raymond R Townsend, David G Edwards

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Sex Differences in Ambulatory Central Blood Pressure and Arterial Stiffness in Hemodialysis Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
    Article
  4. Article
  5. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Danielle L KirkmanDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0003-1648-0662
Meghan G RamickDepartment of Kinesiology, West Chester University, West Chester, Pennsylvania.
Bryce J MuthSchool of Health Sciences, Stockton University, Galloway Township, New Jersey.ORCID 0000-0002-1483-5469
Joseph M StockDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.ORCID 0000-0002-9866-415X
Raymond R TownsendPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-3215-9118
David G EdwardsDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.ORCID 0000-0002-5098-6678
University of Delaware · USStockton University · USUniversity of Pennsylvania · USVirginia Commonwealth University · USWest Chester University · US

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
Exercise and Vascular Function in Chronic Kidney DiseaseR01HL113514 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G · 2013 to 2015
$1.2M
NHLBI NIH HHS R01 HL113514NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD). Abnormal arterial hemodynamics contribute to CVD, a relationship that can be mediated by microvascular dysfunction. The purpose of this study was to investigate potential sex differences in arterial hemodynamics and microvascular dysfunction in patients with stages 3 to 4 CKD. Vascular function was assessed in 22 male (mean ± SD; age, 56 ± 13 yr) and 10 female (age, 63 ± 9 yr) patients. Arterial hemodynamics were acquired with combined tonometry and oscillometry. Skin blood flow was used as a model of microvascular function. Participants were instrumented with three microdialysis fibers for the delivery of

Indexed as

Cardiovascular DiseasesRenal Insufficiency, ChronicAcetophenonesAdultAgedCyclic N-OxidesFemaleHemodynamicsHumansMaleMiddle AgedNADPH OxidasesSex CharacteristicsSpin LabelsVasodilationAcetophenonesacetovanilloneCyclic N-OxidesNADPH OxidasesSpin Labelstempolarterial hemodynamicschronic kidney diseasemicrovascular functionoxidative stresssex differences

Identifiers

PMID36269643
PMCPMC9678402
OpenAlexW4307036293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.