Observational studyDiabetes/metabolism research and reviews2023
Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment.
Observational study in Diabetes/metabolism research and reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Phase angle and triglyceride-glucose index as biomarkers of glycemic control, body composition and cardiovascular risk in adolescents with type 1 diabetes: a cross-sectional study.Journal of endocrinological investigation · 2026Article
- The Bidirectional Relationship Between Type 1 Diabetes Mellitus and Obesity in Pediatric Patients: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Relationship between body adiposity and glycemic control in children and adolescents with type 1 diabetes.Acta diabetologica · 2026Article
- Sex Differences in the Association Between Body Composition and Cognitive Performance in Adolescents With Type 1 Diabetes.Diabetes/metabolism research and reviews · 2026Observational
- The virtual Morris water maze for cognitive function assessment in adolescents with type 1 diabetes.Diabetologia · 2026Article
- Body composition in prepubertal children with idiopathic premature adrenarche: implications for cardiometabolic health.Pediatric research · 2025Observational
- Seasonal Variations in HbA1c and Body Composition: A Sex-Specific Analysis in Adolescents With Type 1 Diabetes.Diabetes/metabolism research and reviews · 2025Observational
- Influence of Sex and Age on Irisin Levels in Pediatric Type 1 Diabetes: A Pilot Study.Journal of clinical medicine · 2025Article
- Glucagon-like peptide-1 agonists: Role of the gut in hypoglycemia unawareness, and the rationale in type 1 diabetes.World journal of diabetes · 2024Article
- Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment.Diabetes/metabolism research and reviews · 2023Observational
- Body composition rather than liver fat associates with carotid Intima-Media thickness in youth with type 1 diabetes.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen with type 1 diabetes (T1D) are more susceptible than men to cardiovascular disease (CVD). Signs of increased risk may already appear among adolescent girls.
objectivesWe explored the contribution of body composition to the development of CVD risk factors among youth with T1D.
methodsOne hundred and eighty nine subjects with T1D (mean age 15.3 ± 5.1 years, 55% boys) followed between January 2018-January 2022 were included in this observational study. Sociodemographic and clinical data were extracted from medical files. Body composition was measured by bioelectrical impedance analysis, and muscle-to-fat ratio (MFR) z-scores were calculated. Logistic regression model assessed the association between body composition (MFR z-scores) and evidence of CVD risk factors.
resultsFemales were characterised by higher median BMI z-scores (0.47 vs. 0.04, p = 0.012), higher fat and truncal fat percentage levels (p ≤ 0.001) and lower median MFR z-scores (-0.64 vs. -0.25, p ≤ 0.001), higher median triglyceride (TG) levels (71 vs. 61 mg/dl, p = 0.05), longer disease duration to initiation of insulin pump therapy (p = 0.041), and more time spent in marked hypoglycemia (1 vs. 0.2%, p = 0.007) than males. Males' MFR z-scores were associated with several diabetes-related parameters (age at diagnosis, CGM metrics, HbA1c and insulin dose), while the females'' MFR z-scores were linked to the atherogenic dyslipidemia index (TG:HDL ratio). The odds for CVD risk factors were doubled for every 1 SD decrease in MFR z-score (OR = 0.50, CI [0.30-0.84], p = 0.009) and also increased with age (OR = 1.07, CI [1.004-1.148], p = 0.038).
conclusionsBody composition measurement has a predictive value in CVD risk assessment in youth with T1D, with unique characteristics and influences in each sex.
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