Evidence map›Paper›PMID 36269535›Full record

ArticleCurrent medical science2023

High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma.

Si-Yu Lan, Yang Ding, Chun Wang, Jun Fang, Chao Ren, Jia-Liang Liu, Hui Kang, Ying Chang

Open access · hybridAbstract read
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In one paragraph

Article in Current medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Ubiquitin-conjugating Enzymes in Cancer.International journal of biological sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Si-Yu LanDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Yang DingDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Chun WangDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Jun FangDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Chao RenDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Jia-Liang LiuDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Hui KangDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Ying ChangDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. changying@whu.edu.cn.
Wuhan University · CNHubei Provincial Center for Disease Control and Prevention · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUbiquitin conjugate enzyme E2O (UBE2O) is a ubiquitin-conjugating enzyme that has been reported to be involved in tumorigenesis. This study investigated the role of UBE2O in hepatocellular carcinoma (HCC).

methodsThe expression of UBE2O was detected using qRT-PCR, Western blotting, and immunohistochemical staining. Cell proliferation and Transwell assays were used to detect proliferation, migration, and invasion of HCC cells, respectively. Bioinformatic analysis was performed to analyze the relationship between UBE2O and the clinical features, prognosis, and immune cell infiltration of HCC.

resultsUBE2O was significantly over-expressed in HCC tissues. High expression of UBE2O was associated with poor tumor grade and poor prognosis. Functional experiments showed that down-regulation of UBE2O inhibited HCC cell proliferation, migration, and invasion. Co-expression gene analysis and gene set enrichment analysis showed that UBE2O was associated with protein hydrolysis, cell cycle, and cancer-related pathways in HCC. The results of immune analysis revealed that the expression of UBE2O was positively correlated with the immune infiltration and expression of immune-related chemokines of HCC.

conclusionsUBE2O is significantly correlated with the prognosis of HCC and may be a valuable prognostic biomarker for HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsCell LineHumansPrognosisUbiquitinUbiquitin-Conjugating EnzymesUBE2O protein, humanUbiquitinUbiquitin-Conjugating Enzymeshepatocellular carcinomaimmuneprognosisubiquitin conjugate enzyme E2O

Identifiers

PMID36269535
OpenAlexW4307034925

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.