Evidence map›Paper›PMID 36269513›Full record

ArticleInflammation2023

Treatment with 1,25-Dihydroxyvitamin D3 Delays Choroid Plexus Infiltration and BCSFB Injury in MRL/lpr Mice Coinciding with Activation of the PPARγ/NF-κB/TNF-α Pathway and Suppression of TGF-β/Smad Signaling.

Xuewei Li, Shuangli Xu, Jie Liu, Yingzhe Zhao, Huirong Han, Xiangling Li, Yanqiang Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. What is known about the effects of vitamin D in neuropsychiatric lupus?Advances in rheumatology (London, England) · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xuewei LiDepartment of Rheumatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Shuangli XuDepartment of Neurology II, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Jie LiuDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Yingzhe ZhaoDepartment of Neurology II, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Huirong HanDepartment of Anesthesiology, Weifang Medical University, Weifang, Shandong, China.
Xiangling LiDepartment of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. lixiangling163@163.com.
Yanqiang WangDepartment of Neurology II, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. wangqiangdoctor@126.com.
Weifang Medical University · CN

Funding

National Natural Science Foundation of China No. 81870943
6 · The paper itself

Abstract

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of systemic lupus erythematosus (SLE) involving the nervous system with high morbidity and mortality. A key hypothesis in NPSLE is that a disrupted barrier allows autoantibodies and immune components of peripheral blood to penetrate into the central nervous system (CNS), resulting in inflammation and damage. The blood cerebrospinal fluid barrier (BCSFB), which consists of the choroid plexus and the hypothalamic tanycytes, has long been regarded as an immunological sanctuary site. 1,25-Dihydroxyvitamin D3 [1,25-(OH)

Indexed as

Lupus Erythematosus, SystemicTumor Necrosis Factor-alphaAnimalsBrain-Derived Neurotrophic FactorCalcitriolChoroid PlexusInflammationMiceMice, Inbred MRL lprNF-kappa BPPAR gammaSmad ProteinsTransforming Growth Factor betaBrain-Derived Neurotrophic FactorCalcitriolNF-kappa BPPAR gammaSmad ProteinsTransforming Growth Factor betaTumor Necrosis Factor-alpha1,25-dihydroxyvitamin D3BCSFB injuryneuropsychiatric systemic lupus erythematosusPPARγ pathwayTGF-β/Smad pathway.

Identifiers

PMID36269513
OpenAlexW4307034883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.