Evidence map›Paper›PMID 36269441›Full record

ArticleJournal of ophthalmic inflammation and infection2022

Successful treatment with repeated dexamethasone implant injections for recurrent macular edema after acute retinal necrosis.

Ragnhild Øvstebø Sørland, Anne Kjersti Erichsen, Thora Elisabet Jonsdottir, Marius Nordberg Bromnes, Peter Mæhre Lauritzen, Jon Roger Eidet

Open access · goldAbstract read
In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ragnhild Øvstebø SørlandDepartment of Ophthalmology, Oslo University Hospital, Oslo, Norway. ragsoe@ous-hf.no.
Anne Kjersti ErichsenDepartment of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Thora Elisabet JonsdottirDepartment of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Marius Nordberg BromnesDepartment of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Peter Mæhre LauritzenDepartment of Radiology, Oslo University Hospital, Oslo, Norway.
Jon Roger EidetDepartment of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe treatment of recurrent cystoid macular edema associated with acute retinal necrosis is challenging due to the concern that treatment with intravitreal steroids may reactivate the retinitis. CASE REPORT: An immunocompetent patient diagnosed with acute retinal necrosis was treated with oral valacyclovir and intravitreal injections of foscarnet. Giant tears in her retina necessitated a vitrectomy with silicone oil. She developed cystoid macular edema after the removal of the silicone oil. The edema responded to high-dose prednisolone but recurred when the dose was tapered to 20 mg daily. Under close surveillance and increased antiviral medication, she was treated with a dexamethasone implant with complete resolution of the edema. Unfortunately, the edema recurred, and the treatment had to be repeated. Over 18 months, she received five dexamethasone implants without recurrence of the viral retinitis.

conclusionsThis case shows successful treatment of recurring cystoid macular edema following acute retinal necrosis with repeated intravitreal dexamethasone implants in a patient receiving valacyclovir maintenance treatment.

Indexed as

Acute retinal necrosisCystoid macular edemaDexamethasone implantValacyclovir

Identifiers

PMID36269441
PMCPMC9587196
OpenAlexW4307032564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.