ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023
Physiological impacts of computed tomography airway dysanapsis, fractal dimension, and branch count in asymptomatic never smokers.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- Integrated assessment of total airway count and pneumonia volume on chest computed tomography as a prognostic biomarker for coronavirus disease.European radiology · 2026Article
- Unsupervised comprehensive CT imaging clusters reveal distinct morphological phenotypes in asthma: insights from two prospective cohorts.Respiratory research · 2026Article
- Distinct central and peripheral airway features in bronchiolitis obliterans and COPD: an observational study.BMC pulmonary medicine · 2026Observational
- A novel quantitative method for CT assessment of bronchiectasis using AI-based airway segmentation and upper limits of normal airway caliber.Respiratory research · 2026Article
- Determinants of airway morphology in asthma: Inflammatory and noninflammatory factors.The journal of allergy and clinical immunology. Global · 2025Article
- Antigravity muscle density on computed tomography and health-related independence in normal weight patients with chronic obstructive pulmonary disease.Respiratory research · 2025Article
- Age-related lung structure changes by quantitative assessment: a cross-sectional study in a Chinese male cohort.Frontiers in aging · 2025Article
- Electroencephalographic differences between waking and sleeping periods in patients with prolonged disorders of consciousness at different levels of consciousness.Frontiers in human neuroscience · 2025Article
- Computed tomography morphological assessments of central airways in interstitial lung abnormalities and idiopathic pulmonary fibrosis.Respiratory research · 2024Article
- Airway Tree Caliber and Susceptibility to Pollution-associated Emphysema: MESA Air and Lung Studies.American journal of respiratory and critical care medicine · 2024Article
- Centrilobular emphysema and airway dysanapsis: factors associated with low respiratory function in younger smokers.ERJ open research · 2024Article
- Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes.EClinicalMedicine · 2024Article
- Quantitative CT Scan Imaging of the Airways for Diagnosis and Management of Lung Disease.Chest · 2023Review
- Airway trees in the Anthropocene.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
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11 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Dysanapsis, a mismatch between airway tree caliber and lung size, contributes to a large variation in lung function on spirometry in healthy subjects. However, it remains unclear whether other morphological features of the airway tree could be associated with the variation in lung function independent of dysanapsis. This study used lung cancer screening chest computed tomography (CT) and spirometry data from asymptomatic never smokers. Dysanapsis and the complexity of airway tree geometry were quantified on CT by measuring airway to lung ratio (ALR) and airway fractal dimension (AFD). Moreover, total airway count (TAC), ratio of airway luminal surface area to volume (SA/V), longitudinal tapering and irregularity of the radius of the internal lumen from the central to peripheral airways (Tapering index and Irregularity index) were quantified. In 431 asymptomatic never smokers without a history of lung diseases, lower ALR was associated with lower forced expiratory volume in 1 s (FEV
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