ArticleJournal of tropical pediatrics2022
Tuberculosis prevalence, incidence and prevention in a south african cohort of children living with HIV.
Article in Journal of tropical pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Incidence rate of tuberculosis among HIV infected children in Ethiopia: systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Epidemiology of Pediatric Tuberculosis in the Western Cape: A Population-Based Study (2017-2023).Pediatrics · 2026Article
- Characteristics and mortality of children living with HIV/TB coinfection in a tertiary hospital in a resource-limited setting.BMC infectious diseases · 2025Observational
- Collaborative learning in the digital age: empowering tuberculosis researchers through virtual training.Journal of microbiology & biology education · 2024Article
- Diagnoses of children living with HIV before and during the COVID-19 pandemic.Southern African journal of infectious diseases · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe describe tuberculosis (TB) disease among antiretroviral treatment (ART) eligible children living with HIV (CLHIV) in South Africa to highlight TB prevention opportunities.
methodsIn our secondary analysis among 0- to 12-year-old ART-eligible CLHIV in five Eastern Cape Province health facilities from 2012 to 2015, prevalent TB occurred 90 days before or after enrollment; incident TB occurred >90 days after enrollment. Characteristics associated with TB were assessed using logistic and Cox proportional hazards regression with generalized estimating equations.
resultsOf 397 enrolled children, 114 (28.7%) had prevalent TB. Higher-income proxy [adjusted odds ratio (aOR) 1.8 [95% confidence interval (CI) 1.3-2.6] for the highest, 1.6 (95% CI 1.6-1.7) for intermediate]; CD4+ cell count <350 cells/µl [aOR 1.6 (95% CI 1.1-2.2)]; and malnutrition [aOR 1.6 (95% CI 1.1-2.6)] were associated with prevalent TB. Incident TB was 5.2 per 100 person-years and was associated with delayed ART initiation [hazard ratio (HR) 4.7 (95% CI 2.3-9.4)], malnutrition [HR 1.8 (95% CI 1.1-2.7)] and absence of cotrimoxazole [HR 2.3 (95% CI 1.0-4.9)]. Among 362 children with data, 8.6% received TB preventive treatment.
conclusionsAmong these CLHIV, prevalent and incident TB were common. Early ART, cotrimoxazole and addressing malnutrition may prevent TB in these children.
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Registered trials
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