ArticlePediatric diabetes2022
Utility of plasma beta-hydroxybutyrate to define resolution of diabetic ketoacidosis.
Article in Pediatric diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Innovations and applications of ketone body monitoring in diabetes care.Diabetology international · 2024Review
- Update on Measuring Ketones.Journal of diabetes science and technology · 2024Review
- Metabolic trajectories of diabetic ketoacidosis onset described by breath analysis.Frontiers in endocrinology · 2024Article
- The role of anion gap normalization time in the management of pediatric diabetic ketoacidosis.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiabetic ketoacidosis (DKA) is a common, life-threatening complication of type 1 diabetes (T1D) characterized by unregulated ketogenesis caused by relative or absolute insulin deficiency. DKA management requires frequent biochemical monitoring. Plasma ß-hydroxybutyrate (BOHB) has not been included in traditional definitions of DKA resolution.
objectiveThe aim of this study was to determine a cut-point level of BOHB to define DKA resolution in patients with T1D treated with intravenous (IV) insulin. SUBJECTS: We identified patients with T1D receiving IV insulin for DKA treatment at a quaternary children's hospital from January 1, 2017 through December 31, 2020 who had plasma measurements of BOHB after DKA onset and whose DKA resolved by traditional laboratory criteria (venous pH (vpH) ≥ 7.3, serum bicarbonate (HCO
methodsAssociations between plasma BOHB and vpH, HCO
resultsWe analyzed 403 patients with 471 unique encounters. Plasma BOHB showed the most robust relationship with AG. The ROC curve comparing plasma BOHB to the accepted definition of DKA resolution, AG ≤14 mmol/L, had an AUC of 0.92. A BOHB value of <1.5 mmol/L had a sensitivity of 83% and specificity of 87%; this cut-point correctly classified 86% of the observations.
conclusionsA plasma BOHB value of <1.5 mmol/L can be used to define resolution of DKA.
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