Evidence map›Paper›PMID 36268528›Full record

ReviewPharmaNutrition2022

Vitamin D status can affect COVID-19 outcomes also in pediatric population.

Michele Miraglia Del Giudice, Cristiana Indolfi, Giulio Dinardo, Fabio Decimo, Alberto Decimo, Angela Klain

Open access · greenAbstract readReview
In one paragraph

Review in PharmaNutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. COVID-19 in Children and Vitamin D.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Cristiana IndolfiDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giulio DinardoDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Fabio DecimoDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alberto DecimoDepartment of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Angela KlainDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease. Results: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population. Conclusions: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.

Indexed as

ACE2, angiotensin-converting enzyme 2ChildrenCI, confidence intervalCOVID-19DAMPs, damage-associated molecular patternsDCs, dendritic cellsHR, Hazard RiskICU, intensive care unit, IFN-γ, reduce interferon-gammaIgE, immunoglobulin EIL, interleukinImmunityMD, mean differenceNK, natural killerOR, odds ratioPAMPs, pathogen-associated molecular patternsPRRs, pattern recognition receptors, RAS, renin-angiotensin systemRCTs, randomized control trialsRR, risk ratioSARS-CoV-2 infectionTLRs, Toll-like receptorsTNF-α, tumor necrosis factor-αTreg cells, CD, regulatory T cellcluster of differentiationVDRs, vitamin D receptorsVitamin D

Identifiers

PMID36268528
PMCPMC9562619
OpenAlexW4306250207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.