Evidence map›Paper›PMID 36268515›Full record

ReviewFrontiers in cell and developmental biology2022

Therapeutic effect of natural polyphenols against glioblastoma.

Ozal Beylerli, Aferin Beilerli, Alina Shumadalova, Xiaoxiong Wang, Mingchun Yang, Hanran Sun, Lei Teng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  9. Article
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  12. Article
  13. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Review
  16. Polyphenon E Effects on Gene Expression in PC-3 Prostate Cancer Cells.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ozal BeylerliРeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Aferin BeilerliDepartment of Obstetrics and Gynecology, Tyumen State Medical University, Tyumen, Russia.
Alina ShumadalovaDepartment of General Chemistry, Bashkir State Medical University, Ufa, Russia.
Xiaoxiong WangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Mingchun YangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hanran SunDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Lei TengDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNBashkir State Medical University · RUPeoples' Friendship University of Russia · RUTyumen State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system, which has a highly invasive growth pattern, which creates poor prospects for patient survival. Chemotherapy and tumor surgery are limited by anticancer drug resistance and tumor invasion. Evidence suggests that combinations of treatments may be more effective than single drugs alone. Natural polyphenolic compounds have potential as drugs for the treatment of glioblastoma and are considered as potential anticancer drugs. Although these beneficial effects are promising, the efficacy of natural polyphenolic compounds in GBM is limited by their bioavailability and blood-brain barrier permeability. Many of them have a significant effect on reducing the progression of glioblastoma through mechanisms such as reduced migration and cell invasion or chemosensitization. Various chemical formulations have been proposed to improve their pharmacological properties. This review summarizes natural polyphenolic compounds and their physiological effects in glioblastoma models by modulating signaling pathways involved in angiogenesis, apoptosis, chemoresistance, and cell invasion. Polyphenolic compounds are emerging as promising agents for combating the progression of glioblastoma. However, clinical trials are still needed to confirm the properties of these compounds

Indexed as

anticancer therapycurcuminflavonoidsglioblastomapolyphenols

Identifiers

PMID36268515
PMCPMC9577362
OpenAlexW4300860607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.