Evidence map›Paper›PMID 36268125›Full record

ArticleACS pharmacology & translational science2022

Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.

Victor Clausse, Yuhong Fang, Dingyin Tao, Harichandra D Tagad, Hongmao Sun, Yuhong Wang, Surendra Karavadhi, Kelly Lane, Zhen-Dan Shi, Olga Vasalatiy and 8 more

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery.SLAS discovery : advancing life sciences R & D · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Victor ClausseSynthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.
Yuhong FangNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Dingyin TaoNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0001-6531-2740
Harichandra D TagadLaboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, United States.
Hongmao SunNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0003-4042-6498
Yuhong WangNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0001-6480-9528
Surendra KaravadhiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Kelly LaneChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland 20850, United States.
Zhen-Dan ShiChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland 20850, United States.
Olga VasalatiyChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland 20850, United States.
Christopher A LeClairNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0002-2746-5938
Rebecca EellsReaction Biology Corporation, 1 Great Valley Parkway, Suite 2, Malvern, Pennsylvania 19355, United States.
Min ShenNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0002-8218-0433
Samarjit PatnaikNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0002-4265-7620
Ettore AppellaLaboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, United States.
Nathan P CoussensMolecular Pharmacology Laboratories, Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0002-5073-442X
Daniel H AppellaSynthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0001-7195-7764
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USReaction Biology Corporation (United States) · US

Funding

Chemically Modified Peptide Nucleic AcidsZ01DK031143 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2005 to 2008
$892k
Intramural NIH HHS Z01 DK031143
6 · The paper itself

Abstract

Wild-type P53-induced phosphatase 1 (WIP1), also known as

Identifiers

PMID36268125
PMCPMC9578142
OpenAlexW4297517061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.