Evidence map›Paper›PMID 36268028›Full record

ArticleFrontiers in immunology2022

Safety and immunogenicity of intradermal administration of fractional dose CoronaVac

Somruedee Chatsiricharoenkul, Suvimol Niyomnaitham, Harry Joshua Posen, Zheng Quan Toh, Paul V Licciardi, Patimaporn Wongprompitak, Thaneeya Duangchinda, Pattarakul Pakchotanon, Warangkana Chantima, Kulkanya Chokephaibulkit

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Somruedee ChatsiricharoenkulSiriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Suvimol NiyomnaithamSiriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Harry Joshua PosenDivision of Infectious Diseases, Hospital for Sick Children, Toronto, ON, Canada.
Zheng Quan TohInfection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Paul V LicciardiInfection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Patimaporn WongprompitakDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Thaneeya DuangchindaMolecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand.
Pattarakul PakchotanonMolecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand.
Warangkana ChantimaDivision of Dengue Hemorrhagic Fever Research Team, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kulkanya ChokephaibulkitSiriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Mahidol University · THSiriraj Hospital · THUniversity of Melbourne · AUHospital for Sick Children · CANational Center for Genetic Engineering and Biotechnology · THNational Science and Technology Development Agency · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a limited supply of COVID-19 vaccines, with less than 20% of eligible populations in low-income countries having received one dose. Intradermal delivery of fractional dose vaccines is one way to improve global vaccine access, but no studies have reported data on intradermal delivery of COVID-19 primary series vaccination. We conducted a pilot study to examine the safety and immunogenicity of three intradermal primary series regimens - heterologous regimen of CoronaVac and ChAdOx1 (CoronaVac-ChAdOx1), homologous regimen of ChAdOx1 (ChAdOx1-ChAdOx1), and homologous regimen of BNT162b2 (BNT162b2-BNT162b2). Each dose was 1/5

Indexed as

COVID-19COVID-19 VaccinesAntibodies, NeutralizingBNT162 VaccineChAdOx1 nCoV-19HumansImmunoglobulin GPilot ProjectsSARS-CoV-2VaccinationAntibodies, NeutralizingBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesImmunoglobulin Gadverse effectCOVID vaccinefractional dose vaccinationheterologous regimenintradermal vaccinevaccine immunogenicityvaccine safety

Identifiers

PMID36268028
PMCPMC9577032
OpenAlexW4300818916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.