Evidence map›Paper›PMID 36268019›Full record

ReviewFrontiers in immunology2022

The role of cancer-associated mesothelial cells in the progression and therapy of ovarian cancer.

Aiping Zheng, Yuhao Wei, Yunuo Zhao, Tao Zhang, Xuelei Ma

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aiping ZhengDivision of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Yuhao WeiWest China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Yunuo ZhaoDivision of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Tao ZhangDivision of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Xuelei MaDivision of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is currently one of the most common malignant tumors in females with poor survival rates around the world, killing about 200,000 women each year. Although great progress has been made in treatment, most patients receiving first-line therapy experience tumor recurrence. The tumor microenvironment plays an important role in regulating the progression and prognosis of ovarian cancer. Cancer-associated mesothelial cells are the main cell population in the tumor microenvironment, which affect the progression, prognosis and chemical resistance of ovarian cancer. Cancer-associated mesothelial cells can also interact with other microenvironmental components, such as exosomes, macrophages, and adipocytes. Some studies have developed drugs targeting cancer-associated mesothelial cells in ovarian cancer to evaluate the therapeutic efficiency. In this review we highlighted the key role of cancer-associated mesothelial cells in the progression and prognosis of ovarian cancer. We also described the progress of cancer-associated mesothelial cells targeted therapy for ovarian cancer. Continued insight into the role of cancer-associated mesothelial cells in ovarian cancer will potentially contribute to the development of new and effective therapeutic regiments.

Indexed as

Neoplasm Recurrence, LocalOvarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansPrognosisTumor Microenvironmentcancer-associated mesothelial cellschemoresistanceovarian cancertumor progressiontumor therapy

Identifiers

PMID36268019
PMCPMC9577001
OpenAlexW4300818949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.