Evidence map›Paper›PMID 36267981›Full record

ArticleFrontiers in oncology2022

Real-time optical imaging of the hypoxic status in hemangioma endothelial cells during propranolol therapy.

Yue Wu, Xiaojuan Yang, Mingrui Zhai, Yi Chen, Xiaoya Lu, Jiandong Ju, Huanqing Zhang, Guanduo Wang, Zhe Zhang, Baocun Zhu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Infantile hemangioma models: is the needle in a haystack?Journal of translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yue WuDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Xiaojuan YangDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Mingrui ZhaiDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yi ChenDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Xiaoya LuDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Jiandong JuDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Huanqing ZhangDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Guanduo WangDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Zhe ZhangDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
Baocun ZhuSchool of Water Conservancy and Environment, University of Jinan, Jinan, China.
Xuan WangDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Zhanwei ChenDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Shengyun HuangDepartment of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Shandong University · CNShandong First Medical University · CNShandong Provincial Hospital · CNUniversity of Jinan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infantile hemangioma (IH) is the most common microvascular tumor of infancy involving the area of head and neck. One of the most important independent risk factors of IH is the hypoxia microenvironment. Fluorescent chemosensor provides a noninvasive intervention, high spatiotemporal resolution, ultrasensitive response, and real-time feedback approach to reveal the hypoxic status of cells. Our research group developed an ultrasensitive fluorescent chemosensor, HNT-NTR, and investigated the potential ability of imaging the hypoxic status of hemangioma-derived endothelial cells (HemECs). In this study, we successfully visualized the propranolol (PRN) treatment in HemECs using NHT-NTR with "Turn-off" sensing method. This chemosensor exhibited high sensitivity and selectivity for optical imaging of hypoxic status with fast responsiveness, real-time feedback and durable photostability of the fluorescent signal. It was also confirmed that HNT-NTR could monitor nitroreductase

Indexed as

fluorescence imagingfluorescent probehemangiomahypoxic statuspropranolol therapy

Identifiers

PMID36267981
PMCPMC9577016
OpenAlexW4300818967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.