Evidence map›Paper›PMID 36267914›Full record

ArticleiScience2022

Transcellular biosynthesis of leukotriene B

Alex Hopke, Tian Lin, Allison K Scherer, Ashley E Shay, Kyle D Timmer, Brittany Wilson-Mifsud, Michael K Mansour, Charles N Serhan, Daniel Irimia, Bryan P Hurley

Abstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. iScience · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. 15-epi-lipoxin AFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  16. A LTBiScience · 2024
    Article
  17. Activation of leukotriene BCellular & molecular immunology · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alex HopkeCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA 02129, USA.
Tian LinHarvard Medical School, Boston, MA 02115, USA.
Allison K SchererHarvard Medical School, Boston, MA 02115, USA.
Ashley E ShayHarvard Medical School, Boston, MA 02115, USA.
Kyle D TimmerDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Brittany Wilson-MifsudMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Michael K MansourHarvard Medical School, Boston, MA 02115, USA.
Charles N SerhanHarvard Medical School, Boston, MA 02115, USA.
Daniel IrimiaCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA 02129, USA.
Bryan P HurleyHarvard Medical School, Boston, MA 02115, USA.

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PETASIS, NICOS A · 2011 to 2020
$14.8M
The Role of Hepoxilin A3 in Neutrophil Breach of the Infected Airway MucosaR01AI095338 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HURLEY, BRYAN P · 2012 to 2022
$5.2M
Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2021 to 2025
$3.6M
The role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI095338NIAID NIH HHS R01 AI132638NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R35 GM139430
6 · The paper itself

Abstract

Neutrophil swarming is an emergent host defense mechanism triggered by targets larger than a single neutrophil's capacity to phagocytose. Swarming synergizes neutrophil functions, including chemotaxis, phagocytosis, and reactive oxygen species (ROS) production, and coordinates their deployment by many interacting neutrophils. The potent inflammatory lipid mediator leukotriene B

Indexed as

Cell biologyImmunology

Identifiers

PMID36267914
PMCPMC9576560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.