Evidence map›Paper›PMID 36267892›Full record

ArticleGreen synthesis and catalysis2021

Synthesis of indoles, indolines, and carbazoles

Alexander J Rago, Guangbin Dong

Open access · diamondAbstract read
In one paragraph

Article in Green synthesis and catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 108 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander J RagoDepartment of Chemistry, University of Chicago, Chicago, IL 60637, United States.
Guangbin DongDepartment of Chemistry, University of Chicago, Chicago, IL 60637, United States.
University of Chicago · US

Funding

New Directions in Palladium/Norbornene Cooperative-RenewalR01GM124414 · NIGMS · UNIVERSITY OF CHICAGO · PI DONG, GUANGBIN · 2018 to 2025
$2.6M
NIGMS NIH HHS R01 GM124414
6 · The paper itself

Abstract

The construction of indole, indoline, and carbazole heterocycles has been of significant interest in the synthetic community over the last century due to their prevalence in natural products and other biologically active compounds. In particular for indoles, many conventional methods developed to date require highly pre-functionalized arene precursors, diminishing their attractiveness as "green" syntheses. Carbon-hydrogen bond activation, on the other hand, presents an elegant solution to this problem and can achieve the construction of indoles and their derivatives from comparatively simpler arene precursors. In this short review, we discuss various approaches for preparing indoles, indolines, and carbazoles

Indexed as

1,4-palladium migrationCarbon–carbon bond formationCarbon–hydrogen bond activationCarbon–nitrogen bond formationHeterocycle synthesisPalladium catalysisPalladium/norbornene cooperative catalysis

Identifiers

PMID36267892
PMCPMC9581343
OpenAlexW3133992902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.