Evidence map›Paper›PMID 36267534›Full record

ArticleThe Saudi dental journal2022

Conditioned-medium of stem cells from human exfoliated deciduous teeth prevent apoptosis of neural progenitors.

Masagus Zainuri, Jan Purba, Sri Wa Jusman, Endang W Bachtiar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Saudi dental journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Masagus ZainuriDoctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Jan PurbaDepartment of Neurology Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Sri Wa JusmanDepartment of Biochemistry & Molecular Biology, Universitas Indonesia, Jakarta, Indonesia.
Endang W BachtiarDepartment of Oral Biology, Faculty of Dentistry and Oral Sciences Research Center, Universitas Indonesia, Jakarta, Indonesia.
University of Indonesia · IDMinistry of Health · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to evaluate the neuroprotective ability of the conditioned medium of stem cells from human exfoliated deciduous teeth (CM-SHED) to prevent glutamate-induced apoptosis of neural progenitors. Materials and methods: Neural progenitors were isolated from two-day-old rat brains, and the conditioned medium was obtained from a mesenchymal stem cell SHED. Four groups were examined: neural progenitor cells cultured in neurobasal medium with (N + ) and without (N-) glutamate and glycine, and neural progenitor cells cultured in CM-SHED with (K + ) and without (K-) glutamate and glycine. Results: The expression of GABA A1 receptor ( Conclusions: CM-SHED may effectively prevent glutamate-induced apoptosis of neural progenitors.

Indexed as

ANOVA, analysis of varianceApoptosisBDNF, brain derived neurotrophic factorCM, conditioned mediumCM-SHED, conditioned medium of stem cells from human exfoliated deciduous teethCREB, cyclic adenosine monophosphate-response element binding proteinELISA, enzyme-linked immunosorbent assayERK, extracellular signal-regulated kinasesGABAAR1, GABA A1 receptorGABA, gamma-aminobutyric acidGAD, glutamic acid decarboxylaseGamma-aminobutyric acidGAPDH, glyceraldehyde-3-phospate dehydrogenasehADSCs, human adipose-derived stem cellsICER, inducible cAMP early repressorJAK/STAT, Janus kinase/ signal transducer and activator of transcriptionMAPK, mitogen activated protein kinasemRNA, messenger RNANeural progenitorNeuroregenerationNMDAR, N-methyl-d-aspartate receptorpCREB, phosphorylated cyclic adenosine monophosphate-response element binding proteinPI3K, phosphoinositide-3-kinasePKC, protein kinase CPSA-NCAM, polysialic acid neural cell adhesion moleculeSecretomeSHED, stem cells from human exfoliated deciduous teethStem cells from human exfoliated deciduous teethTGF, transforming growth factorTrkB, tropomyosin receptor kinase B

Identifiers

PMID36267534
PMCPMC9577352
OpenAlexW4292978210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.