Evidence map›Paper›PMID 36267401›Full record

ArticleFrontiers in genetics2022

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation.

Congrong Wang, Rossella Alfano, Brigitte Reimann, Janneke Hogervorst, Mariona Bustamante, Immaculata De Vivo, Michelle Plusquin, Tim S Nawrot, Dries S Martens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Congrong WangCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Rossella AlfanoCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Brigitte ReimannCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Janneke HogervorstCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Mariona BustamanteISGlobal, Barcelona, Spain.
Immaculata De VivoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Michelle PlusquinCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Tim S NawrotCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Dries S MartensCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Hasselt University · BEBarcelona Institute for Global Health · ESHarvard University · USKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, no study yet has reported how the interplay between genetic variants and genome-wide cytosine methylation explains the variation in early-life telomere length. In this study based on 281 mother-newborn pairs from the ENVIR

Indexed as

ageingDNA methylationgenetic variantsmediation and effect modificationmQTLnewborntelomere

Identifiers

PMID36267401
PMCPMC9576874
OpenAlexW4301398469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.