Evidence map›Paper›PMID 36267258›Full record

ArticleOpen forum infectious diseases2022

Amikacin Liposomal Inhalation Suspension in the Treatment of

Raphael Chiron, Wouter Hoefsloot, Jakko Van Ingen, Hélène Marchandin, Laurent Kremer, Hélène Morisse-Pradier, Jeremy Charriot, Jean-Pierre Mallet, Jean-Louis Herrmann, Davide Caimmi and 12 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Microorganisms · 2025
    Review
  4. Article
  5. Article
  6. Observational
  7. Growing from common ground: nontuberculous mycobacteria and bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  8. Therapy ofMicroorganisms · 2024
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 12 institutions in 3 countries.

Raphael ChironHydroSciences Montpellier, Centre National de la Recherche pour la Santé (CNRS), Institut de Recherche pour le Développement (IRD), Université Montpellier, Montpellier, France.
Wouter HoefslootPulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Jakko Van IngenDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Hélène MarchandinHydroSciences Montpellier, Centre National de la Recherche pour la Santé (CNRS), Institut de Recherche pour le Développement (IRD), Université Montpellier, Montpellier, France.
Laurent KremerInstitut de Recherche en Infectiologie de Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique UMR 9004, Université Montpellier, Montpellier, France.
Hélène Morisse-PradierQuantif-LITIS Laboratory EA 4108, Rouen University, Rouen, France.
Jeremy CharriotRespiratory Diseases Department, University Hospital Centre Montpellier, Montpellier, France.
Jean-Pierre MalletRespiratory Diseases Department, University Hospital Centre Montpellier, Montpellier, France.
Jean-Louis HerrmannUniversité Paris-Saclay, Hopital Raymond Poincaré, GHU-AP-HP, Paris, France.
Davide CaimmiCF Center, University Hospital Centre Montpellier, Montpellier, France.
Johan MoreauPhyMedExp, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche pour la Santé (CNRS), Montpellier, France.
Yann DumontLaboratoire de bactériologie, University Hospital Centre Montpellier, MIVEGEC, IRD-CNRS-UM, Montpellier, France.
Sylvain GodreuilLaboratoire de bactériologie, University Hospital Centre Montpellier, MIVEGEC, IRD-CNRS-UM, Montpellier, France.
Anne BergeronService de Pneumologie, AP-HP, Hôpital Saint-Louis, Paris, France.
Margot DrevaitCF Center, University Hospital Centre Montpellier, Montpellier, France.
Elodie Bouzat-RossigneuxCentre Hospitalier Universitaire Pointe-à-Pitre Abymes, Pointe-a-Pitre, Guadeloupe, France.
Nicolas TerrailPharmacy Department, University Hospital Centre Montpellier, Montpellier, France.
Claire AndrejakRespiratory Department, Centre Hospitalier Universitaire (CHU) Amiens-Picardie, Avenue Laënenc, Amiens, France.
Nicolas VezirisCentre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, AP-HP, Paris, France.
Dominique GrenetPneumologie et Transplantation Pulmonaire, Hopital Foch, Suresnes, France.
Alexandre CoudratCF Center, University Hospital Centre Montpellier, Montpellier, France.
Emilie CatherinotPneumology Department, Hôpital Foch, Suresnes, France.
Centre Hospitalier Universitaire de Montpellier · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Foch · FRInstitut de Recherche pour le Développement · FRRadboud University Medical Center · NLCentre de Recherche Épidémiologie et Statistique · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Nîmes · FRCentre Hospitalier Universitaire Pointe-à-Pitre · GPInserm · FRLaboratoire d'Informatique, du Traitement de l'Information et des Systèmes · FRUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Based on a retrospective observational cohort study, we investigated the safety and efficacy of amikacin liposome inhaled suspension (ALIS) as an adjunct to a standard antibiotic regimen for Results: Twenty-six patients had long-term follow-up data available. Culture conversion was achieved in 54% (14/26) of the patients with no difference between CF and non-CF patients after an average treatment duration of 10 months. Patient treatment compliance was significantly better in the converter group compared to nonconverters with an odds ratio of 44.78 associated with good compared to poor patient compliance. Overall, 9 patients (35%) experienced an adverse event that led to treatment discontinuation. Conclusions: ALIS appears beneficial in both CF and non-CF populations with

Indexed as

amikacin liposomal inhalation suspensioncystic fibrosisMycobacterium abscessusnontuberculous mycobacteriatreatment

Identifiers

PMID36267258
PMCPMC9578164
OpenAlexW4295159940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.