ArticleOpen forum infectious diseases2022
Polymicrobial Foot Infection Patterns Are Common and Associated With Treatment Failure.
Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Microenvironment shapesiScience · 2026Article
- Rationales for Antibiotic Treatment Versus Direct Surgical Resection in Various Strata of Diabetic Foot Osteomyelitis-Literature Review and Expert Opinions.Antibiotics (Basel, Switzerland) · 2026Article
- Imaging and clinical features of emphysematous osteomyelitis.Skeletal radiology · 2026Article
- Community context influences the conjugation efficiency ofFEMS microbes · 2024Article
- Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes.World journal of clinical cases · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: That foot infections are predominately polymicrobial has long been recognized, but it is not clear if the various species co-occur randomly or in patterns. We sought nonrandom species co-occurrence patterns that might help better predict prognosis or guide antimicrobial selection. Methods: We analyzed tissue (bone, skin, and other soft tissue), fluid, and swab specimens collected from initial foot infection episodes during a 10-year period using a hospital registry. Nonrandom co-occurrence of microbial species was identified using simple pairwise co-occurrence rates adjusted for multiple comparisons, Markov and conditional random fields, and factor analysis. A historical cohort was used to validate pattern occurrence and identify clinical significance. Results: In total, 156 unique species were identified among the 727 specimens obtained from initial foot infection episodes in 694 patients. Multiple analyses suggested that Conclusions: Several nonrandom microbial co-occurrence patterns are frequently seen in foot infection specimens. One particular pattern with many
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