ArticleFrontiers in neuroscience2022
Lead location as a determinant of motor benefit in subthalamic nucleus deep brain stimulation for Parkinson's disease.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the neuroprotective effect of GLP-1 receptor agonists in parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease.Annals of neurology · 2023Trial
- Long-lasting concordance between imaging-guided and clinical-based STN-DBS programming enhances motor and axial outcomes in Parkinson's disease: A 3-year single-center study.Journal of Parkinson's disease · 2026Article
- A novel methodology for localizing pallidal deep brain stimulation leads.Frontiers in neuroanatomy · 2026Article
- Validation of automated image-guided programming in STN-DBS for Parkinson's disease.Frontiers in human neuroscience · 2026Article
- Clinical predictors of speech changes after subthalamic neurostimulation in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Concordance between imaging and clinical based STN-DBS programming improves motor outcomes of directional stimulation in Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Image-guided optimization of current steering in STN-DBS for Parkinson's disease.Frontiers in neurology · 2025Article
- Patient-specific and interpretable deep brain stimulation optimisation using MRI and clinical review data.Frontiers in neuroscience · 2025Article
- "PICS": a novel patient-specific landmark for thalamic surgical interventions in the posterior limb of the internal capsule signal.Frontiers in human neuroscience · 2025Article
- Movement-related increases in subthalamic activity optimize locomotion.Cell reports · 2024Article
- Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Ultra-high-field 7T MRI in Parkinson's disease: ready for clinical use?-a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Applicability of clinical genetic testing for deep brain stimulation treatment in monogenic Parkinson's disease and monogenic dystonia: a multidisciplinary team perspective.Frontiers in neuroscience · 2023Article
- Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis.Frontiers in neurology · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) is regarded as an effective treatment for patients with advanced Parkinson's disease (PD). Clinical benefit, however, varies significantly across patients. Lead location has been hypothesized to play a critical role in determining motor outcome and may account for much of the observed variability reported among patients. Objective: To retrospectively evaluate the relationship of lead location to motor outcomes in patients who had been implanted previously at another center by employing a novel visualization technology that more precisely determines the location of the DBS lead and its contacts with respect to each patient's individually defined STN. Methods: Anatomical models were generated using novel imaging in 40 PD patients who had undergone bilateral STN DBS (80 electrodes) at another center. Patient-specific models of each STN were evaluated to determine DBS electrode contact locations with respect to anterior to posterior and medial to lateral regions of the individualized STNs and compared to the change in the contralateral hemi-body Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) motor score. Results: The greatest improvement in hemi-body motor function was found when active contacts were located within the posterolateral portion of the STN (71.5%). Motor benefit was 52 and 36% for central and anterior segments, respectively. Active contacts within the posterolateral portion also demonstrated the greatest reduction in levodopa dosage (77%). Conclusion: The degree of motor benefit was dependent on the location of the stimulating contact within the STN. Although other factors may play a role, we provide further evidence in support of the hypothesis that lead location is a critical factor in determining clinical outcomes in STN DBS.
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