Evidence map›Paper›PMID 36267138›Full record

ArticleFrontiers in dental medicine2021

Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort.

Rasha N Alotaibi, Brian J Howe, Lina M Moreno Uribe, Consuelo Valencia Ramirez, Claudia Restrepo, Frederic W B Deleyiannis, Carmencita Padilla, Ieda M Orioli, Carmen J Buxó, Jacqueline T Hecht and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in dental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. WDR72 Is Required for Urinary Acidification and Normal HActa physiologica (Oxford, England) · 2026
    Article
  7. Dissecting the Genetic Contribution of Tooth Agenesis.International journal of molecular sciences · 2025
    Review
  8. An Evaluation of Dental Caries Status in Children with Oral Clefts: A Cross-Sectional Study.International journal of environmental research and public health · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Rasha N AlotaibiDental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Brian J HoweDepartment of Family Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA.
Lina M Moreno UribeThe Iowa Center for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.
Consuelo Valencia RamirezClinica Noel, Medellin, Colombia.
Claudia RestrepoClinica Noel, Medellin, Colombia.
Frederic W B DeleyiannisUCHealth Medical Group, Colorado Springs, CO, USA.
Carmencita PadillaDepartment of Pediatrics, College of Medicine, University of the Philippines, Manila.
Ieda M OrioliDepartment of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Carmen J BuxóSchool of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.
Jacqueline T HechtDepartment of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas, TX, USA.
George L WehbyDepartment of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA.
Katherine NeiswangerCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jeffery C MurrayDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
John R ShafferCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Seth M WeinbergCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
University of Iowa · USUniversity of Pittsburgh · USKing Saud University · SAThe University of Texas Health Science Center at Houston · USUniversidade Federal do Rio de Janeiro · BRUniversity of Colorado Health · USUniversity of Puerto Rico System · PRUniversity of the Philippines Manila · PH

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., MOROU-BERMUDEZ, EVANGELIA · 2020 to 2024
$17.7M
MOLECULAR STUDIES IN NONSYNDROMIC CLEFT LIP AND PALATER01DE011931 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLANTON, SUSAN HALLORAN, HECHT, JACQUELINE T · 1999 to 2017
$7.6M
Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
Genetic and Environmental Risks for Oral Clefts in Puerto Rican HispanicsR00DE024571 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BUXO, CARMEN J. · 2018 to 2021
$1.2M
Human genomics analysis interface for FaceBase 2U01DE024425 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2014 to 2018
$1.2M
Planning International Orofacial Cleft Genetic StudiesR21DE016930 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L · 2006 to 2007
$293k
Genetic and Environmental Risks for Oral Clefts in Puerto Rican HispanicsK99DE024571 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BUXO, CARMEN J. · 2014 to 2015
$254k
NCBDD CDC HHS R01 DD000295NIDCR NIH HHS K99 DE024571NIDCR NIH HHS R00 DE024571NIDCR NIH HHS R01 DE011931NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R21 DE016930NIDCR NIH HHS R37 DE008559NIDCR NIH HHS U01 DE024425NIGMS NIH HHS U54 GM133807
6 · The paper itself

Abstract

Odontogenesis is a complex process, where disruption can result in dental anomalies and/or increase the risk of developing dental caries. Based on previous studies, certain dental anomalies tend to co-occur in patients, suggesting that these traits may share common genetic and etiological components. The main goal of this study was to implement a multivariate genome-wide association study approach to identify genetic variants shared between correlated structural dental anomalies and dental caries. Our cohort (

Indexed as

CorrelationDental AnomaliesDental CariesMulti-ethnicMultivariate GWAS

Identifiers

PMID36267138
PMCPMC9581442
OpenAlexW4205152773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.