Evidence map›Paper›PMID 36267108›Full record

ArticleJournal of clinical & translational endocrinology2022

Coronary artery disease in patients with cystic fibrosis - A case series and review of the literature.

Zahrae Sandouk, Noura Nachawi, Richard Simon, Jennifer Wyckoff, Melissa S Putman, Sarah Kiel, Sarah Soltman, Antoinette Moran, Amir Moheet

2 registry-linked trialsOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & translational endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
NCT07692594 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Cardiovascular Health in People With Cystic Fibrosis

Typeobservational_patient_registrySponsorLiverpool Heart and Chest Hospital NHS Foundation TrustRan2026 to 2028Enrolled32ConditionsCystic Fibrosis (CF), Cardiovascular (CV) Risk, Flow-mediated Dilation Evaluation of the Brachial Artery, Pulse Wave Analysis
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. The endocrine complications of cystic fibrosis.Nature reviews. Endocrinology · 2026
    Review
  3. The impact of elexacaftor-tezacaftor-ivacaftor on cardiometabolic risk factors: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Review
  5. Article
  6. 20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  7. Review
  8. Review
  9. The ageing of people living with cystic fibrosis: what to expect now?European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Zahrae SandoukDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Noura NachawiDivision of Endocrinology, Cleveland Clinic, Cleveland, OH, USA.
Richard SimonDivision of Pulmonology, University of Michigan, Ann Arbor, MI, USA.
Jennifer WyckoffDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Melissa S PutmanDivisions of Endocrinology, Massachusetts General Hospital and Boston Children's Hospital, MA, USA.
Sarah KielDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Minnesota. Minneapolis, MN, USA.
Sarah SoltmanDivision of Endocrinology, Oregon Health and Sciences University, Portland, OR, USA.
Antoinette MoranDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Amir MoheetDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
University of Michigan–Ann Arbor · USUniversity of Minnesota · USCleveland Clinic · USMassachusetts General Hospital · USOregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive obstructive pulmonary disease is the primary life-shortening complication in people with Cystic Fibrosis (CF); improvement in life expectancy has led to increased prevalence of non-pulmonary complications. Patients with CF are considered to be at low risk for coronary artery disease (CAD). We report here a case series of six patients with CF with and without known cystic fibrosis related diabetes (CFRD) who had acute myocardial infarction (AMI) requiring coronary stent placement. This was a heterogeneous group of patients, without a clear pattern of consistent risk factors. Interestingly, most patients in this cohort had low LDL. In this review, we discuss risk factors of cardiovascular disease (CVD) that may apply to the CF population. While CAD is rare in people with CF, it does occur. We postulate that the risk will grow with increased longevity and the increased prevalence of co-morbidities such as obesity and dyslipidemia.

Indexed as

Coronary artery diseaseCystic fibrosisCystic fibrosis related diabetesHyperlipidemiaLow cholesterol levelRisk factors

Identifiers

PMID36267108
PMCPMC9576554
OpenAlexW4302028698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.