Evidence map›Paper›PMID 36266933›Full record

ArticleZoological research2023

Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling.

Yu Yan, Dong Ik Park, Anja Horn, Mari Golub, Christoph W Turck

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yu YanProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich 80804, Germany.
Dong Ik ParkProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich 80804, Germany.
Anja HornLudwig-Maximilians-Universität, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Munich 80336, Germany.
Mari GolubDepartment of Environmental Toxicology, University of California, Davis, CA 95616, USA.
Christoph W TurckProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich 80804, Germany. E-mail: turck@psych.mpg.de.
University of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
NIH HHS P51 OD011107
6 · The paper itself

Abstract

Fluoxetine (Prozac™) is the only antidepressant approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in children. Despite its considerable efficacy as a selective serotonin reuptake inhibitor, the possible long-term effects of fluoxetine on brain development in children are poorly understood. In the current study, we aimed to delineate molecular mechanisms and protein biomarkers in the brains of juvenile rhesus macaques (

Indexed as

FluoxetineMajor Depressive DisorderAnimalsBiomarkersMacaca mulattaProteomicsSelective Serotonin Reuptake InhibitorsUnited StatesBiomarkersFluoxetineSelective Serotonin Reuptake InhibitorsFluoxetineGABAergic synapseMajor depressive disorderProteomicsRhesus monkeys

Identifiers

PMID36266933
PMCPMC9841182
OpenAlexW4307034079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.