ArticleAnimal models and experimental medicine2022
Could a phase model help to improve translational animal research?
Article in Animal models and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma.Animal models and experimental medicine · 2025Article
- Establishment and evaluation of an improved rat model of open abdomen.Animal models and experimental medicine · 2024Article
- "Blind men and an elephant": The need for animals in research, drug safety studies, and understanding civilizational diseases.Animal models and experimental medicine · 2023Article
- Could a phase model help to improve translational animal research?Animal models and experimental medicine · 2022Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnimal models are widely applied in medical research for different purposes. In particular, results from translational experiments may be used for subsequent clinical development. However, transferability of these findings to the human organism is controversial. Among other factors, this may be traced back to a lack of clear differentiation of the evidence (explorative vs. confirmatory) provided by such experimental results. In general, inferential statistics (i.e. p values) should not be interpreted in as confirmatory unless crucial methodological requirements are met.
methodsTherefore, we propose a phase model which reflects the well-established process of clinical research, and we discuss its potential to improve decision making in translational research. The model aims to clarify the reliability of results derived from animal models.
resultsThe phase model proposes subdividing translational, pre-clinical research into pilot, exploration, and confirmation phases. Experiments for which there is no valid estimation of the expected effect size are designated as pilot studies. Based on these data, experiments in subsequent phases may be planned using both appropriate design and statistical methods.
conclusionSeparating the entire process of translational animal research into three phases could contribute to improved transparency of the evidence derived from such experiments.
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