ArticleAlzheimer's research & therapy2022
Development and clinical validation of CT-based regional modified Centiloid method for amyloid PET.
Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition.Nature communications · 2025Pooled it
- Impact of adjunctive quantitative analysis on visual interpretation of amyloid PET: a multiple tracer, multicentre study.European radiology · 2026Article
- Low-dose CT for MRI-free quantification of tau PET in Alzheimer's disease: a multicentre, cross-sectional, comparison study.The Lancet medical imaging & theranostics · 2026Article
- Integrative analysis of AT classification, plasma biomarkers, and cognitive trajectories across diverse dementia syndromes.Scientific reports · 2025Article
- Potential utility of plasma pTau217 for assessing amyloid and tau biomarker profiles.European journal of nuclear medicine and molecular imaging · 2025Article
- Centiloid values from deep learning-based CT parcellation: a valid alternative to freesurfer.Alzheimer's research & therapy · 2025Article
- Concordance between Centiloid Quantification and Visual Interpretation of Amyloid PET Scans across the Alzheimer Disease Continuum.AJNR. American journal of neuroradiology · 2025Article
- Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures.Scientific reports · 2025Article
- Integrating visual assessments and quantification methods for tau PET staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Reproducibility of Plasma Biomarker Measurements Across Laboratories: Insights Into ptau217, GFAP, and NfL.Dementia and neurocognitive disorders · 2025Article
- Establishing Regional Aβ Cutoffs and Exploring Subgroup Prevalence Across Cognitive Stages Using BeauBrain AmyloDementia and neurocognitive disorders · 2025Article
- Comprehensive Clinical and Behavioral Characteristics of Mild Cognitive Impairment According to Amyloid Positivity: A Large Multi-Center Korean Cohort.Dementia and neurocognitive disorders · 2025Article
- Physical Activity, Alzheimer Plasma Biomarkers, and Cognition.JAMA network open · 2025Article
- Comparison of accumulation rates of beta-amyloid tracers and their relationship with cognitive changes.Scientific reports · 2025Article
- Temporal Dynamics and Biological Variability of Alzheimer Biomarkers.JAMA neurology · 2025Article
- Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Factors associated with cognitive reserve according to education level.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD): A Cohort for Dementia Research and Ethnic-Specific Insights.Dementia and neurocognitive disorders · 2024Article
- Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Different associations between body mass index and Alzheimer's markers depending on metabolic health.Alzheimer's research & therapy · 2024Article
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10 authors.
Funding
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Abstract
backgroundThe standard Centiloid (CL) method was proposed to harmonize and quantify global
methodsFor development of MRI-based or CT-based rdcCLs, the cohort consisted of 63 subjects (20 young controls (YC) and 18 old controls (OC), and 25 participants with Alzheimer's disease dementia (ADD)). We performed a direct comparison of the FMM-FBB rdcCL method using MRI and CT images to define a common target region and the six regional VOIs of frontal, temporal, parietal, posterior cingulate, occipital, and striatal regions. Global and regional rdcCL scales were compared between MRI-based and CT-based methods. For clinical validation, the cohort consisted of 2245 subjects (627 CN, 933 MCI, and 685 ADD).
resultsBoth MRI-based and CT-based rdcCL scales showed that FMM and FBB were highly correlated with each other, globally and regionally (R
conclusionsOur findings suggest that it is feasible to convert regional FMM or FBB rdcSUVR values into rdcCL scales without additional MRI scans. This allows a more easily accessible method for researchers that can be applicable to a variety of different conditions.
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