Evidence map›Paper›PMID 36266631›Full record

ArticleBMC medical imaging2022

Quantitative DCE-MRI prediction of breast cancer recurrence following neoadjuvant chemotherapy: a preliminary study.

Rajat Thawani, Lina Gao, Ajay Mohinani, Alina Tudorica, Xin Li, Zahi Mitri, Wei Huang

Abstract read
In one paragraph

Article in BMC medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rajat ThawaniDivision of Hematology and Oncology, Knight Cancer Institute, Oregon Health & Science University, Sam Jackson Park Road, OCH14110, 97239, Portland, OR, US. thawani@ohsu.edu.
Lina GaoBiostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, US.
Ajay MohinaniDepartment of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, US.
Alina TudoricaDepartment of Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, US.
Xin LiAdvanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, US.
Zahi MitriDivision of Hematology and Oncology, Knight Cancer Institute, Oregon Health & Science University, Sam Jackson Park Road, OCH14110, 97239, Portland, OR, US.
Wei HuangAdvanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, US.

Funding

Shutter-Speed Model DCE-MRI for Assessment of Response to Cancer TherapyU01CA154602 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HUANG, WEI, RYAN, CHRISTOPHER WALTER · 2011 to 2015
$2.9M
Multicenter Quantitative MRI Assessment of Breast Cancer Therapy ResponseR01CA248192 · NCI · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI WEI HUANG, James H Holmes · 2021 to 2026
$2.8M
NCI NIH HHS R01 CA248192NCI NIH HHS U01 CA154602
6 · The paper itself

Abstract

introductionBreast cancer patients treated with neoadjuvant chemotherapy (NACT) are at risk of recurrence depending on clinicopathological characteristics. This preliminary study aimed to investigate the predictive performances of quantitative dynamic contrast-enhanced (DCE) MRI parameters, alone and in combination with clinicopathological variables, for prediction of recurrence in patients treated with NACT.

methodsForty-seven patients underwent pre- and post-NACT MRI exams including high spatiotemporal resolution DCE-MRI. The Shutter-Speed model was employed to perform pharmacokinetic analysis of the DCE-MRI data and estimate the K

resultsPre- and post-NACT DCE-MRI parameters performed better than tumor size measurement in prediction of recurrence, whether alone or in combination with clinicopathological variables. Combining post-NACT K

conclusionAccurate prediction of recurrence pre- and/or post-NACT through integration of imaging markers and clinicopathological variables may help improve clinical decision making in adjusting NACT and/or adjuvant treatment regimens to reduce the risk of recurrence and improve survival outcome.

Indexed as

Breast NeoplasmsNeoadjuvant TherapyContrast MediaFemaleHumansMagnetic Resonance ImagingNeoplasm Recurrence, LocalTreatment OutcomeContrast MediaBreast cancerDynamic contrast-enhanced (DCE) MRINeoadjuvant chemotherapyRecurrenceTransfer rate constant (Ktrans)

Identifiers

PMID36266631
PMCPMC9585714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.