Evidence map›Paper›PMID 36266600›Full record

ArticleMolecular imaging and biology2023

Immuno-PET Monitoring of CD8

Hasan Alsaid, Shih-Hsun Cheng, Meixia Bi, Fang Xie, Mary Rambo, Tinamarie Skedzielewski, Bao Hoang, Sunish Mohanan, Debra Comroe, Andrew Gehman and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  2. Article
  3. Review
  4. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

Hasan AlsaidBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA. hasan.5.alsaid@gsk.com.ORCID http://orcid.org/0000-0001-6600-2146
Shih-Hsun ChengBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Meixia BiImmuno-Oncology Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
Fang XieBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Mary RamboBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Tinamarie SkedzielewskiBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Bao HoangBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Sunish MohananNon-Clinical Safety, IVIVT, GlaxoSmithKline, Collegeville, PA, USA.
Debra ComroeIntegrated Biological Platform Sciences, GlaxoSmithKline, Collegeville, PA, USA.
Andrew GehmanResearch Statistics, GlaxoSmithKline, Collegeville, PA, USA.
Chih-Yang HsuBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Kamyar FarhangiBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Hoang TranResearch Statistics, GlaxoSmithKline, Collegeville, PA, USA.
Valeriia SherinaResearch Statistics, GlaxoSmithKline, Collegeville, PA, USA.
Minh DoanBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
M Reid GrosecloseBioimaging, IVIVT, GlaxoSmithKline, Collegeville, PA, 19426, USA.
Christopher B HopsonImmuno-Oncology Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
Sara BrettOncology Cell Therapy Research Unit, GlaxoSmithKline, Hertfordshire, UK.
Ian A WilsonImaginAb, Inglewood, CA, USA.
Andrew NichollsBioimaging, IVIVT, GlaxoSmithKline, Hertfordshire, UK.
Marc BallasOncology Clinical Development, GlaxoSmithKline, Collegeville, PA, USA.
Jeremy D WaightImmuno-Oncology Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
Beat M JuckerClinical Imaging, GlaxoSmithKline, Collegeville, PA, USA.
GlaxoSmithKline (United States) · USGlaxoSmithKline (United Kingdom) · GBImaginAb (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe presence and functional competence of intratumoral CD8 PROCEDURES: Female BALB/c mice with established EMT6 tumors received 10 µg, IP of either IgG control antibodies, ICOS agonist monotherapy, or ICOS/PD-1 combination therapy on days 0, 3, 5, 7, 9, 10, or 14. Imaging was performed at 24 and 48 h post IV dose of

results

conclusionTo our knowledge, this is the first detailed description of the use of a novel immune-PET imaging technique to assess the kinetics of CD8

Indexed as

CD8-Positive T-LymphocytesNeoplasmsAnimalsCell Line, TumorFemaleImmunoglobulin GInducible T-Cell Co-Stimulator ProteinMicePositron-Emission TomographyPositron Emission Tomography Computed TomographyProgrammed Cell Death 1 ReceptorIcos protein, mouseImmunoglobulin GInducible T-Cell Co-Stimulator ProteinProgrammed Cell Death 1 Receptor89Zr PET imagingCD8+ T cellsICOS agonistImaging mass cytometryPD-1 blockingRadiomics

Identifiers

PMID36266600
PMCPMC10172244
OpenAlexW4306888887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.