ArticleNature biomedical engineering2023
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Gamma entrainment as a functional target in deep brain stimulation.Neural regeneration research · 2026Article
- Neurotechnology-enabled closed-loop optogenetics for modulating autoimmune glial responses in experimental ADEM.Annals of medicine and surgery (2012) · 2026Article
- Modulation of place cells using targeted stimulation with bidirectional microelectrode arrays enhances spatial learning speed in mice.Fundamental research · 2026Article
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Active pixel power control for crosstalk-free all-optical neural interrogation.Nature communications · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Closed-loop optogenetic control of cell biology enables outcome-driven microscopy.Nature communications · 2025Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Diverse species of animal models in epilepsy research: Progress and perspectives.Zoological research · 2025Review
- A software platform for real-time and adaptive neuroscience experiments.Nature communications · 2025Article
- RpiBeh offers a versatile open source solution for rodent behavior tracking and closed loop interventions.Scientific reports · 2025Article
- KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications.Nature communications · 2025Article
- Recent Advances in Flexible Sensors for Neural Interfaces: Multimodal Sensing, Signal Integration, and Closed-Loop Feedback.Biosensors · 2025Review
- On brain stimulation in epilepsy.Brain : a journal of neurology · 2025Review
- On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies.Nature communications · 2025Article
- Nonlinear model predictive control of a conductance-based neuron model via data-driven forecasting.Journal of neural engineering · 2024Article
- Intan Technologies integrated circuits can produce analog-to-digital conversion artifacts that affect neural signal acquisition.Journal of neural engineering · 2024Article
- A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level.Nature communications · 2024Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- Wireless closed-loop deep brain stimulation using microelectrode array probes.Journal of Zhejiang University. Science. B · 2024Review
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 3 countries.
Funding
Abstract
Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its applications to open-loop stimuli. Real-time and continuous closed-loop control of brain activity can, however, be achieved by pairing concurrent electrical recordings and optogenetics. Here we show that closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates. The approach generates oscillations in quiescent tissue, enhances or suppresses endogenous patterns in active tissue and modulates seizure-like bursts elicited by the convulsant 4-aminopyridine. A nonlinear model of the phase-dependent effects of optical stimulation reproduced the modulation of cycles of local-field potentials associated with seizure oscillations, as evidenced by the systematic changes in the variability and entropy of the phase-space trajectories of seizures, which correlated with changes in their duration and intensity. We also show that closed-loop optogenetic neurostimulation could be delivered using intracortical optrodes incorporating light-emitting diodes. Closed-loop optogenetic approaches may be translatable to therapeutic applications in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.