Evidence map›Paper›PMID 36266520›Full record

ArticleCellular and molecular life sciences : CMLS2022

METTL3 modulates chromatin and transcription dynamics during cell fate transition.

Xiao-Min Liu, Yuanhui Mao, Shen Wang, Jun Zhou, Shu-Bing Qian

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The mFrontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. m6A epitranscriptomic and epigenetic crosstalk in cardiac fibrosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Xiao-Min Liu *School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China. liuxm642@cpu.edu.cn.ORCID http://orcid.org/0000-0002-9258-4087
Yuanhui Mao *Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Shen WangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China.
Jun ZhouSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China.
Shu-Bing QianDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA. sq38@cornell.edu.
China Pharmaceutical University · CNCornell University · USZhejiang Chinese Medical University · CN

Funding

Dynamic mRNA m6A modification in oncogenic translationR21CA227917 · NCI · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2018 to 2019
$371k
Basic Research Program of Jiangsu Province BK20190533Basic Research Program of Jiangsu Province BK20211219Foundation for the National Institutes of Health R21CA227917Howard Hughes Medical Institute 55108556National Natural Science Foundation of China 32070868National Natural Science Foundation of China 81974527NCI NIH HHS R21 CA227917
6 · The paper itself

Abstract

Transcriptional programming plays a key role in determining the cell state. Timely reconfiguration of chromatin structure and attenuation of pluripotent genes are required for efficient embryonic stem cell (ESC) differentiation. Here, we identify METTL3, a core N

Indexed as

ChromatinEmbryonic Stem CellsCell DifferentiationHistone CodeMethyltransferasesPromoter Regions, GeneticChromatinMethyltransferasesCell differentiationChromatin accessibilityMETTL3Transcription

Identifiers

PMID36266520
PMCPMC11803071
OpenAlexW4306950853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.