ArticleNature genetics2022
Discovery of 42 genome-wide significant loci associated with dyslexia.
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations.Nature communications · 2025Pooled it
- Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities.Translational psychiatry · 2022Pooled it
- Neural Cell Models of Specific Reading Disabilities: Identification of Cellular and Transcriptome Alterations.Genes, brain, and behavior · 2026Article
- Electrophysiological Correlates of Familial Dyslexia in Two Siblings: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Mouse predation is dependent on a population of POU6F2-positive retinal ganglion cells.iScience · 2026Article
- Shared genetics between ADHD and reading/language abilities: Genome-wide correlations, stratified enrichment, cross-trait association, and mendelian randomization.JCPP advances · 2026Article
- Genome-wide investigation of prosody perception: Shared genetic influences between speech rhythm, musical rhythm, and reading traits.HGG advances · 2026Article
- Towards disentangling the polygenic contribution of dyslexia to school performance.Translational psychiatry · 2026Article
- The Genetic Origin of Uneven Cognitive Profiles in Heritable Neurodevelopmental Conditions and Individual Differences: Computational Investigations.Developmental science · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Rapid decay of perceptual memory in dyslexia.Trends in cognitive sciences · 2026Review
- Transcriptome-wide association study of prostate cancer in the Chinese population.Asian journal of urology · 2026Article
- Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.iScience · 2026Article
- Natural selection and language genes in humans.Scientific reports · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Article
- Toward an Improved Understanding of Dyslexia: Reflections on a New Consensus Definition and Its Implications.Dyslexia (Chichester, England) · 2026Article
- Gene Expression-Based Lesion-Symptom Mapping:The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Measuring reading and language skill in generation Scotland: Scottish Family Health Study.BMJ public health · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
29 authors at 20 institutions in 16 countries.
Funding
Abstract
Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.