Trial reportScientific reports2022
Effect of a light-darkness cycle on the body weight gain of preterm infants admitted to the neonatal intensive care unit.
Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05230706 (Application of a Light/Dark Cycle in Preterm Neonates and Its Association With Shorter In-hospital Stay), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of a Light/Dark Cycle in Preterm Neonates and Its Association With Shorter In-hospital Stay
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects on Weight Gain and Length of Hospital Stay of Day and Night-Cycled Light Exposure in Premature Infants: A Meta-Analysis.The journal of nursing research : JNR · 2025Pooled it
- Cycled light in the intensive care unit for preterm and low birth weight infants.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis.Frontiers in neurologyPooled it
- Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- The role of light exposure in infant circadian rhythm establishment: A scoping review perspective.European journal of pediatrics · 2024Article
- Outcome of creating clustering nursing care and healing environment on premature infants' behavioural outcomes.BMJ paediatrics open · 2024Article
- Best evidence summary of sleep protection in premature infants in the neonatal intensive care unit: a narrative review.Translational pediatrics · 2024Review
- Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?Nutrients · 2024Review
- The Effect of Incubator Cover on Newborn Vital Signs: The Design of Repeated Measurements in Two Separate Groups with No Control Group.Children (Basel, Switzerland) · 2023Article
- Characterizing light-dark cycles in the Neonatal Intensive Care Unit: a retrospective observational study.Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Continuous bright light conditions to which premature infants are subjected while hospitalized in Neonatal Intensive Care Units (NICU) can have deleterious effects in terms of growth and development. This study evaluates the benefits of a light/darkness cycle (LDC) in weight and early hospital discharge from the NICU. Subjects were recruited from three participating institutions in Mexico. Eligible patients (n = 294) were premature infants who were hospitalized in the low-risk and high-risk neonatal units classified as stable. The subjects randomized to the experimental group (n = 150) were allocated to LDC conditions are as follows: light from 07:00 to 19:00 and darkness (25 lx) from 19:00 to 07:00. The control group (n = 144) was kept under normal room light conditions (CBL) 24 h a day. Main outcome was weight gain and the effect of reducing the intensity of nocturnal light in development of premature infants. Infants to the LDC gained weight earlier, compared with those randomized to CBL, and had a significant reduction in length of hospital stay. These results highlight those premature infants subjected to a LDC exhibit improvements in physiological development, favoring earlier weight gain and consequently a decrease in hospital stays. ClinicalTrials.gov; 02/09/2020 ID: NCT05230706.
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