ArticleScientific reports2022
Recapitulation of the embryonic transcriptional program in holometabolous insect pupae.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 10 citations in OpenAlex.
- Transcriptomic analysis reveals that high-protein artificial diet enhances reproductive performance of Protaetia brevitarsis (Lewis) (Coleoptera: Scarabaeidae).Journal of insect science (Online) · 2026Article
- Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.Nucleic acids research · 2026Article
- Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget.Scientific reports · 2025Article
- Temporal Dynamics of Gene Expression During Metamorphosis in Two Distant Drosophila Species.Genome biology and evolution · 2025Article
- Multiple developmental pathways in organisms with developmentally complex life cycles.Frontiers in cell and developmental biology · 2025Review
- Multivariate Time Series Change-Point Detection with a Novel Pearson-like Scaled Bregman Divergence.Stats · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Holometabolous insects are predominantly motionless during metamorphosis, when no active feeding is observed and the body is enclosed in a hardened cuticle. These physiological properties as well as undergoing processes resemble embryogenesis, since at the pupal stage organs and systems of the imago are formed. Therefore, recapitulation of the embryonic expression program during metamorphosis could be hypothesized. To assess this hypothesis at the transcriptome level, we have performed a comprehensive analysis of the developmental datasets available in the public domain. Indeed, for most datasets, the pupal gene expression resembles the embryonic rather than the larval pattern, interrupting gradual changes in the transcriptome. Moreover, changes in the transcriptome profile during the pupa-to-imago transition are positively correlated with those at the embryo-to-larvae transition, suggesting that similar expression programs are activated. Gene sets that change their expression level during the larval stage and revert it to the embryonic-like state during the metamorphosis are enriched with genes associated with metabolism and development.
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