ArticleNature immunology2022
SUSD2 suppresses CD8
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- YKL-40 alleviates the TNF-α-Induced chondrocyte injury in osteoarthritis in vitro.Scientific reports · 2026Article
- SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagyEuropean journal of histochemistry : EJH · 2026Article
- SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin-FAK Signaling Activation.Cancer science · 2026Article
- The cytokine CSBF inhibits the IL-17A and TNF-α inflammatory pathways via SUSD2-ACT1 in keratinocytes and alleviates IMQ-induced psoriasis.Cellular & molecular immunology · 2025Article
- O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism.Nature communications · 2025Article
- SUSD2Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population.Inflammatory bowel diseases · 2025Article
- Induction of SUSD2 by STAT3 Activation Is Associated with Tumor Recurrence in HER2-Positive Breast Cancer.Cells · 2024Article
- Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer.Immunity · 2024Review
- Eosinophils promote CD8Signal transduction and targeted therapy · 2024Article
- Application of Carbon Nanomaterials to Enhancing Tumor Immunotherapy: Current Advances and Prospects.International journal of nanomedicine · 2024Review
- Sushi Domain Containing 2 Dysfunction Contributes to Cancer Progression in Patients with Bladder Cancer.Journal of Cancer · 2024Article
- Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma.Current medicinal chemistry · 2024Article
- Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives.Cell death & disease · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 1 country.
Bao ZhaoDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-3599-1230
Weipeng GongDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Anjun MaDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Jianwen ChenDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Maria VelegrakiPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Hong DongDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Zihao LiuDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Lingling WangPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Tamio OkimotoPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Devin M JonesDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Yu L LeiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9868-9824
Meixiao LongPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Kenneth J OestreichDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3004-072X
Qin MaPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3264-8392
Gang XinDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
David P CarbonePelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Kai HePelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Zihai LiPelotonia Institute for Immuno-Oncology, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-4603-927X
Haitao WenDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University, Columbus, OH, USA. Haitao.Wen@osumc.edu.ORCID http://orcid.org/0000-0002-6363-2748
The Ohio State University · USUniversity of Michigan · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MRestoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3MRobust Immuno-prevention Strategies for High-Risk Oral Epithelial DysplasiaU01DE029255 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRENNER, JOHN CHADWICK, LEI, YU LEO · 2019 to 2021
$4.2MMolecular chaperones and immune toleranceR01AI077283 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2009 to 2021
$3.7MTargeting GRP94-TGF-beta Pathway for Cancer Immunotherapy SupplementR01CA262069 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2021 to 2025
$2.9MTargeting immune inhibitory molecule SUSD2 to reverse immunosuppressionR01AI162779 · NIAID · OHIO STATE UNIVERSITY · PI WEN, HAITAO · 2021 to 2025
$2.3MIdentifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9MConstruction of cell specific gene co-regulations signatures based on single cell transcriptomics analysisR01GM131399 · NIGMS · SOUTH DAKOTA STATE UNIVERSITY · PI MA, QIN · 2018 to 2021
$1.3MMitochondrial metabolism in microbial sepsisR01GM135234 · NIGMS · OHIO STATE UNIVERSITY · PI WEN, HAITAO · 2019 to 2022
$1.2MNCI NIH HHS P30 CA016058NCI NIH HHS R01 CA262069NIAID NIH HHS R01 AI077283NIAID NIH HHS R01 AI134972NIAID NIH HHS R01 AI162779NIDCR NIH HHS R01 DE026728NIDCR NIH HHS U01 DE029255NIGMS NIH HHS R01 GM131399NIGMS NIH HHS R01 GM135234
Abstract
Dysfunctional CD8
Indexed as
CD8-Positive T-LymphocytesNeoplasmsAnimalsCell Line, TumorImmunotherapyMembrane GlycoproteinsMiceMice, Inbred C57BLReceptors, Interleukin-2Signal TransductionTumor MicroenvironmentMembrane GlycoproteinsReceptors, Interleukin-2SVS-1 protein, mouse
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.