Evidence map›Paper›PMID 36266346›Full record

ReviewNature reviews. Microbiology2023

Architecture of the dynamic fungal cell wall.

Neil A R Gow, Megan D Lenardon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed.

  1. Article
  2. Plant signaling & behavior · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Applied and environmental microbiology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Early Cellular Responses ofAntibiotics (Basel, Switzerland) · 2026
    Article
  19. Article
  20. Review

128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Neil A R GowMedical Research Council Centre for Medical Mycology, School of Biosciences, University of Exeter, Exeter, UK. n.gow@exeter.ac.uk.ORCID 0000-0002-2776-5850
Megan D LenardonSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia. m.lenardon@unsw.edu.au.ORCID 0000-0002-9471-7402

Funding

Medical Research Council MR/J008230/1Medical Research Council MR/M026663/2Medical Research Council MR/V033417/1Wellcome Trust 101873/Z/13/ZWellcome Trust 200208/A/15/ZWellcome Trust 215599/Z/19/Z
6 · The paper itself

Abstract

The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system. The cell wall must be robust but flexible, protective and shielding yet porous to nutrients and membrane vesicles and receptive to exogenous signals. Most fungi have a common inner wall skeleton of chitin and β-glucans that functions as a flexible viscoelastic frame to which a more diverse set of outer cell wall polymers and glycosylated proteins are attached. Whereas the inner wall largely determines shape and strength, the outer wall confers properties of hydrophobicity, adhesiveness, and chemical and immunological heterogeneity. The spatial organization and dynamic regulation of the wall in response to prevailing growth conditions enable fungi to thrive within changing, diverse and often hostile environments. Understanding this architecture provides opportunities to develop diagnostics and drugs to combat life-threatening fungal infections.

Indexed as

beta-GlucansGlucansAntifungal AgentsCell WallChitinFungal ProteinsAntifungal Agentsbeta-GlucansChitinFungal ProteinsGlucans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.