Evidence map›Paper›PMID 36266240›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2022

Editorial: Accelerated epigenetic ageing as a consequence of early environmental adversity.

Barbara Franke

Abstract readEditorialComment
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In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Barbara FrankeDepartment of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this editorial, I discuss findings and implications of a hypothesis-generating study by Copeland and colleagues showing that early adverse events related to unpredictability as well as a cumulative score summarising environmental adversity in childhood and adolescence are linked to accelerated epigenetic ageing. The setting of this study is the longitudinal Great Smoky Mountains Study, a richly phenotyped longitudinal cohort with biological information. In my discussion, I focus on potential mechanisms behind the reported findings and opportunities for next steps, for example provided by the richness of data in the cohort used in this study.

Indexed as

AgingEpigenesis, GeneticAdolescentHumansDNA methylationenvironmental adversityepigenetic ageingGreat Smoky Mountains Study

Identifiers

PMID36266240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.