Evidence map›Paper›PMID 36266052›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2022

Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8

Nail Benallegue, Bryan Nicol, Juliette Lasselin, Severine Bézie, Lea Flippe, Hadrien Regue, Nadege Vimond, Severine Remy, Alexandra Garcia, Fabienne Le Frère and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. CD8 regulatory T cell therapy in transplantation: a new path to clinical success?Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nail BenallegueFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Bryan NicolFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Juliette LasselinFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Severine BézieFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Lea FlippeFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Hadrien RegueFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Nadege VimondFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Severine RemyFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Alexandra GarciaFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Fabienne Le FrèreFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Ignacio AnegonFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
David LaplaudFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France.
Carole GuillonneauFrom the Nantes Université (N.B., B.N., J.L., S.B., L.F., H.R., N.V., S.R., A.G., I.A., D.L., C.G.), INSERM, CNRS, Center for Research in Transplantation et Translational Immunology, UMR 1064; and CHU Nantes (F.L.F.), Nantes Université, Service de Neurologie, Centre de Ressources et de Compétences Sclérose en Plaques, Nantes, France. carole.guillonneau@univ-nantes.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the CNS. Studies of immune dysfunction in MS have mostly focused on CD4

methodsWe enrolled adults with relapsing-remitting MS and age-matched and sex-matched healthy volunteers (HVs). CD8

resultsThirty-one untreated patients with relapsing-remitting MS were compared with 40 age-matched and sex-matched HVs. We demonstrated no difference of CSF CD8 DISCUSSION: Altogether, these results suggest a defect in the number and function of CD8

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingAdultAnimalsCD8-Positive T-LymphocytesForkhead Transcription FactorsHumansInterferon-gammaMiceMice, Inbred C57BLRatsT-Lymphocytes, RegulatoryTransforming Growth Factor betaForkhead Transcription FactorsInterferon-gammaTransforming Growth Factor beta

Identifiers

PMID36266052
PMCPMC9621606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.