Evidence map›Paper›PMID 36265902›Full record

ArticleGenes & development2022

Intrinsically disordered protein regions are required for cell wall homeostasis in

Yannick R Brunet, Cameron Habib, Anna P Brogan, Lior Artzi, David Z Rudner

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. CenIR, an essential BlaIR-family regulatory system inbioRxiv : the preprint server for biology · 2026
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  7. ThebioRxiv : the preprint server for biology · 2025
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  11. Computational function prediction of bacteria and phage proteins.Microbiology and molecular biology reviews : MMBR · 2025
    Review
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  18. Identification of a family of peptidoglycan transpeptidases reveals thatProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yannick R BrunetDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cameron HabibDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Anna P BroganDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Lior ArtziDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-0236-7143
Harvard University · US

Funding

Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Growth and differentiation in Bacillus subtilisR35GM145299 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID Z RUDNER · 2022 to 2026
$2.9M
Cell Envelope Homeostasis in Bacillus subtilisR01GM127399 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM086466NIGMS NIH HHS R01 GM127399NIGMS NIH HHS R35 GM145299
6 · The paper itself

Abstract

Intrinsically disordered protein regions (IDRs) have been implicated in diverse nuclear and cytoplasmic functions in eukaryotes, but their roles in bacteria are less clear. Here, we report that extracytoplasmic IDRs in

Indexed as

Bacillus subtilisIntrinsically Disordered ProteinsBacterial ProteinsCell WallGene Expression Regulation, BacterialHomeostasisBacterial ProteinsIntrinsically Disordered ProteinsaGPCRclass A PBPintrinsically disordered protein regionmechanotransductionNotchpeptidoglycanregulated intramembrane proteolysis (RIP)

Identifiers

PMID36265902
PMCPMC9732909
OpenAlexW4306941921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.