Evidence map›Paper›PMID 36265082›Full record

ArticleOrganic letters2022

Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.

Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, Euan Hossack, S Mark Roe, Daren Fearon, Daniel Akinbosede, Stephen Hare, John Spencer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 30 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Storm Hassell-HartDepartment of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.
Elisa SperanziniDepartment of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.
Sirihathai SrikwanjaiDepartment of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.
Euan HossackDepartment of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K.
S Mark RoeDepartment of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K.
Daren FearonDiamond LightSource (DLS), Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.ORCID 0000-0003-3529-7863
Daniel AkinbosedeDepartment of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K.
Stephen HareDepartment of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K.
John SpencerDepartment of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.ORCID 0000-0001-5231-8836
University of Sussex · GBDiamond Light Source · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.

Indexed as

IridiumThiazolesBacteriaCatalysisSulfurfanetizoleIridiumSulfurThiazoles

Identifiers

PMID36265082
PMCPMC9641659
OpenAlexW4306898258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.