Evidence map›Paper›PMID 36264886›Full record

ArticleAmerican journal of physiology. Renal physiology2023

The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis.

Jill W Verlander, Hyun-Wook Lee, Susan M Wall, Autumn N Harris, I David Weiner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Uncoupling proximal tubule ammoniagenesis from bicarbonate generation byAmerican journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Lack of a role of NHE4 in renal ammonia metabolism.American journal of physiology. Renal physiology · 2025
    Article
  4. Revisiting voltage-coupled HAmerican journal of physiology. Renal physiology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jill W VerlanderDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-4096-4897
Hyun-Wook LeeDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Susan M WallRenal Division, Emory University, Atlanta, Georgia.ORCID 0000-0003-2786-8849
Autumn N HarrisDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-2329-3905
I David WeinerDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-0046-0600
University of Florida · USEmory University · USUnited States Department of Veterans Affairs · US

Funding

OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
Sex Differences in Renal Ammonia MetabolismK08DK120873 · NIDDK · UNIVERSITY OF FLORIDA · PI HARRIS, AUTUMN N · 2019 to 2023
$952k
NIDDK NIH HHS K08 DK120873NIDDK NIH HHS R01 DK107798NIDDK NIH HHS R01 DK110375
6 · The paper itself

Abstract

The renal response to acid-base disturbances involves phenotypic and remodeling changes in the collecting duct. This study examines whether the proximal tubule controls these responses. We examined mice with genetic deletion of proteins present only in the proximal tubule, either the A variant or both A and B variants of isoform 1 of the electrogenic Na

Indexed as

AcidosisKidney Tubules, CollectingSodium-Bicarbonate SymportersAnimalsGlycoproteinsKidney Tubules, ProximalMiceMice, KnockoutProton-Translocating ATPasesGlycoproteinsProton-Translocating ATPasesSlc4a4 protein, mouseSodium-Bicarbonate Symporterscollecting ductintercalated cellproximal tubule

Identifiers

PMID36264886
PMCPMC9762982
OpenAlexW4306898515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.