Evidence map›Paper›PMID 36264827›Full record

ArticleScience (New York, N.Y.)2022

Refactored genetic codes enable bidirectional genetic isolation.

Jérôme F Zürcher, Wesley E Robertson, Tomás Kappes, Gianluca Petris, Thomas S Elliott, George P C Salmond, Jason W Chin

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Beyond the Usual Suspects: EmergingInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  18. Antibacterial carbon dots.Materials today. Bio · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jérôme F ZürcherMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-0719-3381
Wesley E RobertsonMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-9812-8288
Tomás KappesDepartment of Biochemistry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5220-2833
Gianluca PetrisMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-2420-6359
Thomas S ElliottMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
George P C SalmondDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Jason W ChinMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-1219-4757
MRC Laboratory of Molecular Biology · GBUniversity of Cambridge · GB

Funding

Medical Research Council MC_U105181009Medical Research Council MC_UP_A024_1008
6 · The paper itself

Abstract

The near-universal genetic code defines the correspondence between codons in genes and amino acids in proteins. We refactored the structure of the genetic code in

Indexed as

Cell EngineeringCodonGenetic CodeGene Transfer, HorizontalAmino AcidsEscherichia coliGenome, BacterialProtein BiosynthesisAmino AcidsCodon

Identifiers

PMID36264827
PMCPMC7614150
OpenAlexW4306902093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.